Melatonin Improves Memory Deficits in Rats with Cerebral Hypoperfusion, Possibly, Through Decreasing the Expression of Small-Conductance Ca2+-Activated K+ Channels
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02820-6
Abstract: This study investigated the expression pattern, regulation of expression, and the role of hippocampal small-conductance Ca2+-activated K+ (SK) channels in memory deficits after cerebral hypoperfusion (CHP) with or without melatonin treatment, in rats. Adults male… read more here.
Keywords: small conductance; expression; conductance ca2; memory deficits ... See more keywords
Small conductance Ca2+-activated K+ channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.05.005
Abstract: Ca2+-activated K+ (KCa) channels regulate after-hyperpolarization in many types of neurons in the central and peripheral nervous system. Small conductance Ca2+-activated K+ (KCa2/SK) channels, a subfamily of KCa channels, are widely expressed in the nervous… read more here.
Keywords: small conductance; ca2 activated; pharmacology; conductance ca2 ... See more keywords
Inhibition of platelet aggregation by activation of platelet intermediate conductance Ca2+‐activated potassium channels
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15827
Abstract: Within the vasculature platelets and endothelial cells play crucial roles in hemostasis and thrombosis. Platelets, like endothelial cells, possess intermediate conductance Ca2+‐activated K+ (IKCa) channels and generate nitric oxide (NO). Although NO limits platelet aggregation,… read more here.
Keywords: conductance ca2; ca2 activated; intermediate conductance; platelet aggregation ... See more keywords
Pregnancy Reprograms Large-Conductance Ca2+-Activated K+ Channel in Uterine ArteriesNovelty and Significance
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DOI: 10.1161/hypertensionaha.117.09059
Abstract: The large-conductance Ca2+-activated K+ (BKCa) channel is of critical importance in pregnancy-mediated increase in uterine artery vasodilation and blood flow. The present study tested the hypothesis that active DNA demethylation plays a key role in… read more here.
Keywords: uterine arteries; pregnancy; large conductance; expression ... See more keywords
Neonatal exposure to sevoflurane caused learning and memory impairment via dysregulating SK2 channel endocytosis
Sign Up to like & getrecommendations! Published in 2021 at "Science Progress"
DOI: 10.1177/00368504211043763
Abstract: Numerous studies have demonstrated that anesthetics’ exposure to neonates imposes toxicity on the developing brain but the underlying mechanisms need to be further elucidated. Our present study aimed to explore the role of small conductance… read more here.
Keywords: activated potassium; small conductance; channel; ca2 activated ... See more keywords
Novel description of the large conductance Ca2+‐modulated K+ channel current, BK, during an action potential from suprachiasmatic nucleus neurons
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DOI: 10.14814/phy2.13473
Abstract: The contribution of the large conductance, Ca2+‐modulated, voltage‐gated K+ channel current, IBK, to the total current during an action potential (AP) from suprachiasmatic nucleus (SCN) neurons is described using a novel computational approach. An experimental… read more here.
Keywords: channel current; large conductance; conductance ca2; current action ... See more keywords
Coronary Large Conductance Ca2+-Activated K+ Channel Dysfunction in Diabetes Mellitus
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DOI: 10.3389/fphys.2021.750618
Abstract: Diabetes mellitus (DM) is an independent risk of macrovascular and microvascular complications, while cardiovascular diseases remain a leading cause of death in both men and women with diabetes. Large conductance Ca2+-activated K+ (BK) channels are… read more here.
Keywords: conductance ca2; ca2 activated; diabetes mellitus; large conductance ... See more keywords
Identification of the Large-Conductance Ca2+-Regulated Potassium Channel in Mitochondria of Human Bronchial Epithelial Cells
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DOI: 10.3390/molecules26113233
Abstract: Mitochondria play a key role in energy metabolism within the cell. Potassium channels such as ATP-sensitive, voltage-gated or large-conductance Ca2+-regulated channels have been described in the inner mitochondrial membrane. Several hypotheses have been proposed to… read more here.
Keywords: large conductance; channel; bronchial epithelial; conductance ca2 ... See more keywords
The Inhibition of the Small-Conductance Ca2+-Activated Potassium Channels Decreases the Sinus Node Pacemaking during Beta-Adrenergic Activation
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15030313
Abstract: Sinus pacemaking is based on tight cooperation of intracellular Ca2+ handling and surface membrane ion channels. An important player of this synergistic crosstalk could be the small-conductance Ca2+-activated K+-channel (ISK) that could contribute to the… read more here.
Keywords: conductance ca2; small conductance; adrenergic activation; beta adrenergic ... See more keywords