Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-021-06045-w
Abstract: Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective We ascertained whether the SK channel is impaired in the… read more here.
Keywords: channel; activated potassium; conductance calcium; activity ... See more keywords
Functional Regulation of Small Conductance Calcium Activated Potassium Channel on Atrial Myocytes by Hydrogen Sulfide in Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2274
Abstract: Previous studies established an essential role for Small Conductance Calcium Activated Potassium(SK) channels in cardiac dysrhythmias, especial in atrial dysrhythmias. Hydrogen sulfide (H2S), an endogenously generated gaseous transmitter, has recently been suggested to regulate cardiovascular… read more here.
Keywords: activated potassium; small conductance; channel; conductance calcium ... See more keywords
Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels.
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-010919-023420
Abstract: The three small-conductance calcium-activated potassium (KCa2) channels and the related intermediate-conductance KCa3.1 channel are voltage-independent K+ channels that mediate calcium-induced membrane hyperpolarization. When intracellular calcium increases in the channel vicinity, it calcifies the flexible N… read more here.
Keywords: pharmacology; conductance calcium; calcium activated; calcium ... See more keywords
Small molecule modulation of the large-conductance calcium-activated potassium channel suppresses salicylate-induced tinnitus in mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.763855
Abstract: Tinnitus is the phantom perception of sound that has no external source. A neurological signature of tinnitus, and the frequently associated hyperacusis, is an imbalance between excitatory and inhibitory activity in the central auditory system… read more here.
Keywords: induced tinnitus; activity; conductance calcium; large conductance ... See more keywords
LY294002 Inhibits Intermediate Conductance Calcium-Activated Potassium (KCa3.1) Current in Human Glioblastoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.790922
Abstract: Glioblastomas (GBs) are among the most common tumors with high malignancy and invasiveness of the central nervous system. Several alterations in protein kinase and ion channel activity are involved to maintain the malignancy. Among them,… read more here.
Keywords: calcium; intermediate conductance; kca3 current; conductance calcium ... See more keywords
External Hemin as an Inhibitor of Mitochondrial Large-Conductance Calcium-Activated Potassium Channel Activity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113391
Abstract: The mitochondrial large-conductance calcium-activated potassium channel (mitoBKCa) is located in the inner mitochondrial membrane and seems to play a crucial role in cytoprotection. The mitoBKCa channel is regulated by many modulators, including activators, such as… read more here.
Keywords: activity; conductance calcium; large conductance; hemin ... See more keywords
Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022179
Abstract: The large-conductance calcium-activated potassium (BK) channel is a critical regulator and potential therapeutic target of vascular tone and architecture, and abnormal expression or dysfunction of this channel is linked to many vascular diseases. Vascular remodelling… read more here.
Keywords: pi3k akt; ctrp7; large conductance; calcium activated ... See more keywords