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Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-021-06045-w
Abstract: Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective We ascertained whether the SK channel is impaired in the…
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Keywords:
channel;
activated potassium;
conductance calcium;
activity ... See more keywords
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Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2274
Abstract: Previous studies established an essential role for Small Conductance Calcium Activated Potassium(SK) channels in cardiac dysrhythmias, especial in atrial dysrhythmias. Hydrogen sulfide (H2S), an endogenously generated gaseous transmitter, has recently been suggested to regulate cardiovascular…
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Keywords:
activated potassium;
small conductance;
channel;
conductance calcium ... See more keywords
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Published in 2019 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-010919-023420
Abstract: The three small-conductance calcium-activated potassium (KCa2) channels and the related intermediate-conductance KCa3.1 channel are voltage-independent K+ channels that mediate calcium-induced membrane hyperpolarization. When intracellular calcium increases in the channel vicinity, it calcifies the flexible N…
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Keywords:
pharmacology;
conductance calcium;
calcium activated;
calcium ... See more keywords
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Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.763855
Abstract: Tinnitus is the phantom perception of sound that has no external source. A neurological signature of tinnitus, and the frequently associated hyperacusis, is an imbalance between excitatory and inhibitory activity in the central auditory system…
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Keywords:
induced tinnitus;
activity;
conductance calcium;
large conductance ... See more keywords
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1
Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.790922
Abstract: Glioblastomas (GBs) are among the most common tumors with high malignancy and invasiveness of the central nervous system. Several alterations in protein kinase and ion channel activity are involved to maintain the malignancy. Among them,…
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Keywords:
calcium;
intermediate conductance;
kca3 current;
conductance calcium ... See more keywords
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1
Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113391
Abstract: The mitochondrial large-conductance calcium-activated potassium channel (mitoBKCa) is located in the inner mitochondrial membrane and seems to play a crucial role in cytoprotection. The mitoBKCa channel is regulated by many modulators, including activators, such as…
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Keywords:
activity;
conductance calcium;
large conductance;
hemin ... See more keywords
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Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022179
Abstract: The large-conductance calcium-activated potassium (BK) channel is a critical regulator and potential therapeutic target of vascular tone and architecture, and abnormal expression or dysfunction of this channel is linked to many vascular diseases. Vascular remodelling…
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Keywords:
pi3k akt;
ctrp7;
large conductance;
calcium activated ... See more keywords