Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation
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DOI: 10.1371/journal.pone.0184605
Abstract: E1784K is the most common mixed long QT syndrome/Brugada syndrome mutant in the cardiac voltage-gated sodium channel NaV1.5. E1784K shifts the midpoint of the channel conductance-voltage relationship to more depolarized membrane potentials and accelerates the… read more here.
Keywords: voltage; conductance voltage; fast inactivation; e1784k ... See more keywords
Large conductance voltage-and calcium-activated K+ (BK) channel in health and disease
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1373507
Abstract: Large Conductance Voltage- and Calcium-activated K+ (BK) channels are transmembrane pore-forming proteins that regulate cell excitability and are also expressed in non-excitable cells. They play a role in regulating vascular tone, neuronal excitability, neurotransmitter release,… read more here.
Keywords: calcium activated; large conductance; voltage calcium; conductance voltage ... See more keywords