GBA RNAi but not catalytic inhibition of glucocerebrosidase with Conduritol-β-epoxide increases levels of total α-synuclein in SH-SY5Y cells
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DOI: 10.1016/j.neulet.2019.05.027
Abstract: Mutations in the glucocerebrosidase gene are a common genetic risk factor for developing Parkinson's disease. The reasons why glucocerebrosidase mutations cause an increased life-time risk of developing Parkinson's disease are not fully understood. Here, we… read more here.
Keywords: glucocerebrosidase; total synuclein; conduritol epoxide; catalytic inhibition ... See more keywords