The Circadian Clock Gene Bmal1 Controls Thyroid Hormone-Mediated Spectral Identity and Cone Photoreceptor Function.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.069
Abstract: Circadian clocks regulate various aspects of photoreceptor physiology, but their contribution to photoreceptor development and function is unclear. Cone photoreceptors are critical for color vision. Here, we define the molecular function of circadian activity within… read more here.
Keywords: bmal1; cone photoreceptor; photoreceptor; function ... See more keywords
A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11513-5
Abstract: Controversially, histone deacetylase inhibitors (HDACi) are in clinical trial for the treatment of inherited retinal degeneration. Utilizing the zebrafish dyeucd6 model, we determined if treatment with HDACi can rescue cone photoreceptor-mediated visual function. dye exhibit… read more here.
Keywords: cone photoreceptor; treatment; model; visual function ... See more keywords
Reduced cone photoreceptor function and subtle systemic manifestations in two siblings with loss of SCLT1.
Sign Up to like & getrecommendations! Published in 2023 at "Ophthalmic genetics"
DOI: 10.1080/13816810.2023.2215332
Abstract: BACKGROUND The sodium channel and clathrin linker 1 gene (SCLT1) has been involved in the pathogenesis of various ciliopathy disorders such as Bardet-Biedl syndrome, orofaciodigital syndrome type IX, and Senior-Løken syndrome. Detailed exams are warranted… read more here.
Keywords: cone photoreceptor; function; reduced cone; photoreceptor function ... See more keywords
The absence of functional bassoon at cone photoreceptor ribbon synapses affects signal transmission at Off cone bipolar cell contacts in mouse retina
Sign Up to like & getrecommendations! Published in 2020 at "Acta Physiologica"
DOI: 10.1111/apha.13584
Abstract: Off cone bipolar cells of the mammalian retina connect to cone photoreceptor synaptic terminals via non‐invaginating flat contacts at a considerable distance from the only established neurotransmitter release site so far, the synaptic ribbon. Diffusion… read more here.
Keywords: cone photoreceptor; cone bipolar; photoreceptor ribbon; ribbon ... See more keywords
The circadian clock mediates the response to oxidative stress in a cone photoreceptor‒like (661W) cell line via regulation of glutathione peroxidase activity.
Sign Up to like & getrecommendations! Published in 2022 at "F1000Research"
DOI: 10.12688/f1000research.125133.2
Abstract: Background: The mammalian retina contains an autonomous circadian clock that controls many physiological functions within this tissue. Our previous studies have indicated that disruption of this circadian clock by removing Bmal1 from the retina affects… read more here.
Keywords: cone photoreceptor; circadian clock; oxidative stress; clock ... See more keywords
Universality of Form: The Case of Retinal Cone Photoreceptor Mosaics
Sign Up to like & getrecommendations! Published in 2023 at "Entropy"
DOI: 10.3390/e25050766
Abstract: Cone photoreceptor cells are wavelength-sensitive neurons in the retinas of vertebrate eyes and are responsible for color vision. The spatial distribution of these nerve cells is commonly referred to as cone photoreceptor mosaic. By applying… read more here.
Keywords: cone photoreceptor; cone; case; universality form ... See more keywords
Delineating the Molecular and Phenotypic Spectrum of the CNGA3-Related Cone Photoreceptor Disorder in Pakistani Families
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13040617
Abstract: Cone photoreceptor dysfunction represents a clinically heterogenous group of disorders characterized by nystagmus, photophobia, reduced central or color vision, and macular dystrophy. Here, we described the molecular findings and clinical manifestations of achromatopsia, a partial… read more here.
Keywords: cone photoreceptor; cone; pakistani families; cnga3 ... See more keywords
Cone Photoreceptor Loss in Light-Damaged Albino Rats
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073978
Abstract: We investigated the etiology of decreased cone-driven vision in a light damage (LD) model of retinal degeneration. To induce slow, moderate degeneration, albino rats underwent low-intensity light exposure for 10 days. Electroretinography was utilized to… read more here.
Keywords: loss; photoreceptor loss; cone; albino rats ... See more keywords