Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli
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DOI: 10.1093/jac/dkx375
Abstract: Abstract Background Ciprofloxacin, a fluoroquinolone, targets two essential bacterial enzymes, DNA gyrase and topoisomerase IV. Plasmid-borne qnr genes, encoding proteins that protect DNA gyrase and topoisomerase IV from inhibition by fluoroquinolones, contribute to resistance development.… read more here.
Keywords: confer clinical; clinical resistance; ciprofloxacin; expression ... See more keywords