Xylose‐Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase
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DOI: 10.1002/cbic.202100396
Abstract: Glucocerebrosidase (GBA), a lysosomal retaining β‐d‐glucosidase, has recently been shown to hydrolyze β‐d‐xylosides and to transxylosylate cholesterol. Genetic defects in GBA cause the lysosomal storage disorder Gaucher disease (GD), and also constitute a risk factor… read more here.
Keywords: xylose configured; gba; cyclophellitols selective; selective inhibitors ... See more keywords