Misclassification of VLCAD carriers due to variable confirmatory testing after a positive NBS result
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DOI: 10.1007/s12687-019-00409-8
Abstract: The Iowa Newborn Screening (NBS) Program began screening for very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) in 2003. Untreated VLCAD can lead to liver failure, heart failure, and death. Current confirmatory testing recommendations by the American… read more here.
Keywords: vlcad; misclassification vlcad; confirmatory testing; vlcad carriers ... See more keywords
Reducing Sanger confirmation testing through false positive prediction algorithms
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DOI: 10.1038/s41436-021-01148-3
Abstract: Purpose Clinical genome sequencing (cGS) followed by orthogonal confirmatory testing is standard practice. While orthogonal testing significantly improves specificity, it also results in increased turnaround time and cost of testing. The purpose of this study… read more here.
Keywords: reducing sanger; confirmatory testing; confirmation testing; false positive ... See more keywords
Correlation of Treponemal Chemiluminescent Microparticle Immunoassay Screening Test Signal Strength Values With Reactivity of Confirmatory Testing
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DOI: 10.1097/olq.0000000000001621
Abstract: When treponemal chemiluminescent microparticle immunoassay signal-to-cutoff ratio is ≥10.4, there is no need for confirmatory testing. This approach obviates the need for secondary treponemal testing in about 71% of the screening-reactive samples. Background Automated chemiluminescent… read more here.
Keywords: ratio; test; chemiluminescent microparticle; confirmatory testing ... See more keywords
High false discovery rate of the Architect anti‐HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing
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DOI: 10.1111/vox.13364
Abstract: Adequate supplies of donor blood remain a major challenge in sub‐Saharan Africa. This is exacerbated by a lack of confirmatory testing for transfusion‐transmitted infections by blood transfusion services (BTS), leading to significant blood disposal owing… read more here.
Keywords: blood donors; false discovery; blood; discovery rate ... See more keywords
Confirmatory testing of Neisseria gonorrhoeae in a sexual health clinic: implications for epidemiology and treatment policy
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DOI: 10.1136/sextrans-2020-054525
Abstract: Objectives European guidelines advise the use of dual nucleic acid amplification tests (NAAT) in order to minimise the inappropriate diagnosis of Neisseria gonorrhoeae (Ng) in urogenital samples from low prevalence areas and in extragenital specimens.… read more here.
Keywords: confirmation; positivity; confirmatory testing; neisseria gonorrhoeae ... See more keywords
The value of confirmatory testing in early infant HIV diagnosis programmes in South Africa: A cost-effectiveness analysis
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DOI: 10.1371/journal.pmed.1002446
Abstract: Background The specificity of nucleic acid amplification tests (NAATs) used for early infant diagnosis (EID) of HIV infection is read more here.
Keywords: diagnosis; hiv; confirmatory testing; art ... See more keywords