Misclassification of VLCAD carriers due to variable confirmatory testing after a positive NBS result
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Community Genetics"
DOI: 10.1007/s12687-019-00409-8
Abstract: The Iowa Newborn Screening (NBS) Program began screening for very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) in 2003. Untreated VLCAD can lead to liver failure, heart failure, and death. Current confirmatory testing recommendations by the American… read more here.
Keywords: vlcad; misclassification vlcad; confirmatory testing; vlcad carriers ... See more keywords
Reducing Sanger confirmation testing through false positive prediction algorithms
Sign Up to like & getrecommendations! Published in 2021 at "Genetics in Medicine"
DOI: 10.1038/s41436-021-01148-3
Abstract: Purpose Clinical genome sequencing (cGS) followed by orthogonal confirmatory testing is standard practice. While orthogonal testing significantly improves specificity, it also results in increased turnaround time and cost of testing. The purpose of this study… read more here.
Keywords: reducing sanger; confirmatory testing; confirmation testing; false positive ... See more keywords
Correlation of Treponemal Chemiluminescent Microparticle Immunoassay Screening Test Signal Strength Values With Reactivity of Confirmatory Testing
Sign Up to like & getrecommendations! Published in 2022 at "Sexually Transmitted Diseases"
DOI: 10.1097/olq.0000000000001621
Abstract: When treponemal chemiluminescent microparticle immunoassay signal-to-cutoff ratio is ≥10.4, there is no need for confirmatory testing. This approach obviates the need for secondary treponemal testing in about 71% of the screening-reactive samples. Background Automated chemiluminescent… read more here.
Keywords: ratio; test; chemiluminescent microparticle; confirmatory testing ... See more keywords
Missed Opportunities for HIV Confirmatory Testing Using an Institutional Testing Algorithm Without Reflex to HIV Nucleic Acid Testing
Sign Up to like & getrecommendations! Published in 2024 at "Sexually Transmitted Diseases"
DOI: 10.1097/olq.0000000000001985
Abstract: A retrospective review found that 35% of those with discordant HIV screening and confirmatory tests at an academic medical center did not undergo confirmatory testing with HIV nucleic acid testing. Abstract At our medical center,… read more here.
Keywords: nucleic acid; confirmatory testing; acid testing; hiv nucleic ... See more keywords
High false discovery rate of the Architect anti‐HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing
Sign Up to like & getrecommendations! Published in 2022 at "Vox Sanguinis"
DOI: 10.1111/vox.13364
Abstract: Adequate supplies of donor blood remain a major challenge in sub‐Saharan Africa. This is exacerbated by a lack of confirmatory testing for transfusion‐transmitted infections by blood transfusion services (BTS), leading to significant blood disposal owing… read more here.
Keywords: blood donors; false discovery; blood; discovery rate ... See more keywords
Confirmatory testing of Neisseria gonorrhoeae in a sexual health clinic: implications for epidemiology and treatment policy
Sign Up to like & getrecommendations! Published in 2021 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2020-054525
Abstract: Objectives European guidelines advise the use of dual nucleic acid amplification tests (NAAT) in order to minimise the inappropriate diagnosis of Neisseria gonorrhoeae (Ng) in urogenital samples from low prevalence areas and in extragenital specimens.… read more here.
Keywords: confirmation; positivity; confirmatory testing; neisseria gonorrhoeae ... See more keywords
The Role of Confirmatory Testing in Carpal Tunnel Syndrome: Electrodiagnostic Study, Ultrasound and CTS-6.
Sign Up to like & getrecommendations! Published in 2024 at "The journal of hand surgery Asian-Pacific volume"
DOI: 10.1142/s2424835525400016
Abstract: Carpal tunnel syndrome (CTS) is the most common upper extremity compressive neuropathy. The reference standard for the diagnosis of CTS remains an area of controversy. The diagnosis can be established clinically, but options for confirmatory… read more here.
Keywords: carpal tunnel; tunnel syndrome; confirmatory testing;
Sparing confirmatory testing in primary aldosteronism (SCIPA): a multicenter retrospective diagnostic accuracy study
Sign Up to like & getrecommendations! Published in 2024 at "BMC Endocrine Disorders"
DOI: 10.1186/s12902-024-01638-w
Abstract: The diagnosis of primary aldosteronism (PA) is comprehensive, which includes case-detection testing, case confirmation followed by subtype classification. In certain instances, such as in the setting of spontaneous hypokalemia, suppressed renin activity (PRA) plus plasma… read more here.
Keywords: confirmatory testing; spontaneous hypokalemia; primary aldosteronism; diagnostic accuracy ... See more keywords
The value of confirmatory testing in early infant HIV diagnosis programmes in South Africa: A cost-effectiveness analysis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Medicine"
DOI: 10.1371/journal.pmed.1002446
Abstract: Background The specificity of nucleic acid amplification tests (NAATs) used for early infant diagnosis (EID) of HIV infection is read more here.
Keywords: diagnosis; hiv; confirmatory testing; art ... See more keywords
Clinical Diagnosis and Laboratory Testing of Abnormal Appearing Toenails: A Retrospective Assessment of Confirmatory Testing for Onychomycosis in the United States, 2022–2023
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Fungi"
DOI: 10.3390/jof10020149
Abstract: Onychomycosis is an under-recognized healthcare burden. Despite the risk of misdiagnosis, confirmatory laboratory testing is under-utilized. Histopathologic examination with polymerase chain reaction (PCR) is currently the most effective diagnostic method; it offers direct detection and… read more here.
Keywords: confirmatory testing; laboratory testing; culture; histopathology ... See more keywords
Confirmatory Testing for Primary Aldosteronism : A Study of Diagnostic Test Accuracy.
Sign Up to like & getrecommendations! Published in 2025 at "Annals of internal medicine"
DOI: 10.7326/annals-24-03153
Abstract: BACKGROUND Confirmatory testing to verify the diagnosis of primary aldosteronism (PA) in patients who have an abnormal screening result is of uncertain benefit. OBJECTIVE To perform a blinded assessment of the seated saline suppression test… read more here.
Keywords: diagnostic test; confirmatory testing; test accuracy; test ... See more keywords