Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα)
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13301
Abstract: 1‐[(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydronaphthalen‐2‐yl)amino]benzotriazole‐5‐carboxylic acid (CBt‐PMN), a partial agonist of retinoid X receptor (RXR), has attracted attention due to its potential to treat type 2 diabetes and central nervous system diseases with reduced adverse effects of existing full… read more here.
Keywords: ligand; conformation; receptor rxr; conformation ligand ... See more keywords
Novel Strategy for Constructing High Efficiency OLED Emitters with Excited State Quinone‐Conformation Induced Planarization Process
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Optical Materials"
DOI: 10.1002/adom.201900283
Abstract: In contrast to the common intramolecular charge transfer (ICT) emission, planarized intramolecular charge transfer (PLICT) based materials usually possess higher proportion radiative decay for their flat and rigid conformation in excited states. Herein, a strategy… read more here.
Keywords: conformation; emitters excited; excited state; conformation induced ... See more keywords
Determination of Amide cis/trans Isomers in N‐Acetyl‐d‐glucosamine: Tailored NMR Analysis of the N‐Acetyl Group Conformation
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200338
Abstract: N‐Acetyl‐d‐glucosamine (GlcNAc) is one of the most common amino sugars in nature, but the conformation of its N‐acetyl group has drawn little attention. We report herein the first identification of NH protons of the amide… read more here.
Keywords: conformation; cis; amide cis; acetyl group ... See more keywords
Is conformation relevant for QSAR purposes? 2D Chemical representation in a 3D-QSAR perspective.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of computational chemistry"
DOI: 10.1002/jcc.26848
Abstract: Conformation has a key role in the mechanism of interaction between small molecules and biological receptors. However, encoding this type of information in molecular descriptors for the construction of robust quantitative structure-activity relationships (QSAR) models… read more here.
Keywords: purposes chemical; qsar purposes; conformation; conformation relevant ... See more keywords
The β8 integrin EGF domains support a constitutive extended conformation, and the cytoplasmic domain impairs outside‐in signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30871
Abstract: Integrins are transmembrane proteins that transmit bi‐directional signals across the cell membrane through global structural rearrangement among three different conformational states: bent, extended‐ closed, and extended‐open conformations. However, the β8 integrin is distinctive and may… read more here.
Keywords: conformation; ligand binding; outside signaling; extended conformation ... See more keywords
Effects of magnetic nanoscale combined radio frequency or microwave thawing on conformation of sea bass myosin heavy chain: a molecular dynamics study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12197
Abstract: BACKGROUND The consumption of frozen foods inevitably involves thawing process. Protein conformation changes during a short thawing process and quantifying their effects is challenging. Molecular dynamics simulations can be used to evaluate the conformational changes… read more here.
Keywords: microwave thawing; molecular dynamics; conformation; radio frequency ... See more keywords
Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23356
Abstract: Type 2 transglutaminase (TG2) functions as an important cancer cell survival protein in a range of cancers including epidermal squamous cell carcinoma. TG2 exists in open and closed conformations each of which has a distinct… read more here.
Keywords: protein; tg2; conformation; gtp binding ... See more keywords
Exploring Helical Folding in Oligomers of Cyclopentane‐Based ϵ‐Amino Acids: A Computational Study
Sign Up to like & getrecommendations! Published in 2022 at "ChemistryOpen"
DOI: 10.1002/open.202100253
Abstract: Abstract The conformational preferences of oligopeptides of an ϵ‐amino acid (2‐((1R,3S)‐3‐(aminomethyl)cyclopentyl)acetic acid, Amc5a) with a cyclopentane substituent in the Cβ−Cγ−Cδ sequence of the backbone were investigated using DFT methods in chloroform and water. The most… read more here.
Keywords: helical folding; conformation; exploring helical; helical conformation ... See more keywords
Changes in dynamic and static structures of the HIV‐1 p24 capsid protein N‐domain caused by amino‐acid substitution are associated with its viral viability
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4184
Abstract: HIV‐1 capsid is comprised of over a hundred p24 protein molecules, arranged as either pentamers or hexamers. Three p24 mutants with amino acid substitutions in capsid N‐terminal domain protein were examined: G60W (α3‐4 loop), M68T… read more here.
Keywords: protein; amino acid; conformation; capsid ... See more keywords
Method of Using Raman Spectroscopy to Understand the Conformation of Fibrous Proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1574-4_20
Abstract: Raman spectroscopy has been widely used in the research of fibrous proteins because of the insensitivity to moisture, less amount of sample, and better signal-to-noise ratio. In recent years, Raman spectroscopy is adopted to investigate… read more here.
Keywords: method using; using raman; conformation; fibrous proteins ... See more keywords
Strain diversity in neurodegenerative disease: an argument for a personalized medicine approach to diagnosis and treatment
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02311-5
Abstract: The protein misfolding mechanism of disease was first described almost 40 years ago in a group of neurodegenerative disorders caused by the prion protein (PrP) [1]. In these diseases, misfolding of cellular PrP (PrPC) into… read more here.
Keywords: medicine; prion; disease; conformation ... See more keywords