Detecting Long-Range Enhancer-Promoter Interactions by Quantitative Chromosome Conformation Capture.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-4035-6_6
Abstract: Chromosome conformation capture (3C) technology and its derivatives are currently the primary methodologies measuring contacts among genomic elements. In fact, the lion share of what is currently known about chromosome folding is based on 3C-related… read more here.
Keywords: detecting long; chromosome; chromosome conformation; conformation capture ... See more keywords
Technical Review: A Hitchhiker's Guide to Chromosome Conformation Capture.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7318-7_14
Abstract: The introduction of chromosome conformation capture (3C) technologies boosted the field of 3D-genome research and significantly enhanced the available toolset to study chromosomal architecture. 3C technologies not only offer increased resolution compared to the previously… read more here.
Keywords: technical review; chromosome conformation; conformation capture;
A chromosome conformation capture ordered sequence of the barley genome.
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22043
Abstract: Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric… read more here.
Keywords: sequence; barley; chromosome conformation; conformation capture ... See more keywords
Orchestrating chromosome conformation capture analysis with Bioconductor
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-44761-x
Abstract: Genome-wide chromatin conformation capture assays provide formidable insights into the spatial organization of genomes. However, due to the complexity of the data structure, their integration in multi-omics workflows remains challenging. We present data structures, computational… read more here.
Keywords: bioconductor; chromosome conformation; conformation capture; conformation ... See more keywords
Improving and correcting the contiguity of long-read genome assemblies of three plant species using optical mapping and chromosome conformation capture data.
Sign Up to like & getrecommendations! Published in 2017 at "Genome research"
DOI: 10.1101/gr.213652.116
Abstract: Long-read sequencing can overcome the weaknesses of short reads in the assembly of eukaryotic genomes; however, at present additional scaffolding is needed to achieve chromosome-level assemblies. We generated Pacific Biosciences (PacBio) long-read data of the… read more here.
Keywords: chromosome conformation; chromosome; optical mapping; conformation capture ... See more keywords
Statistics of randomly cross-linked polymer models to interpret chromatin conformation capture data.
Sign Up to like & getrecommendations! Published in 2017 at "Physical Review E"
DOI: 10.1103/physreve.96.012503
Abstract: Polymer models are used to describe chromatin, which can be folded at different spatial scales by binding molecules. By folding, chromatin generates loops of various sizes. We present here a statistical analysis of the randomly… read more here.
Keywords: capture data; cross linked; polymer models; conformation capture ... See more keywords
A Comparative Study for Identifying the Chromosome-Wide Spatial Clusters from High-Throughput Chromatin Conformation Capture Data
Sign Up to like & getrecommendations! Published in 2018 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2017.2684800
Abstract: In the past years, the high-throughput sequencing technologies have enabled massive insights into genomic annotations. In contrast, the full-scale three-dimensional arrangements of genomic regions are relatively unknown. Thanks to the recent breakthroughs in High-throughput Chromosome… read more here.
Keywords: negative matrix; conformation capture; non negative; spatial clusters ... See more keywords
The Significance of Chromosome Conformation Capture in 3D Genome Architecture Comprehension
Sign Up to like & getrecommendations! Published in 2025 at "Current Bioinformatics"
DOI: 10.2174/0115748936368122250404050711
Abstract: Chromosomes are intricate macromolecules composed of chromatin that create threedimensional structures within cells. The arrangement and interactions of chromosomes play a crucial role in shaping the genome’s structure, function, and gene expression regulation. To fully… read more here.
Keywords: architecture; significance chromosome; conformation capture; conformation ... See more keywords
Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1129207
Abstract: Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS), remains challenging.… read more here.
Keywords: chromosome conformation; ankylosing spondylitis; conformation; conformation capture ... See more keywords