Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα)
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13301
Abstract: 1‐[(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydronaphthalen‐2‐yl)amino]benzotriazole‐5‐carboxylic acid (CBt‐PMN), a partial agonist of retinoid X receptor (RXR), has attracted attention due to its potential to treat type 2 diabetes and central nervous system diseases with reduced adverse effects of existing full… read more here.
Keywords: ligand; conformation; receptor rxr; conformation ligand ... See more keywords
ESR1 mutations associated with EIS change conformation of ligand receptor complex and alter transcriptome profile.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrinology"
DOI: 10.1210/endocr/bqaa050
Abstract: Estrogen insensitivity syndrome (EIS) arises from rare mutations in estrogen receptor α (ERα, encoded by ESR1 gene) resulting in the inability of estrogen to exert its biological effects. Due to the rarity, mutations in ESR1… read more here.
Keywords: change conformation; receptor; conformation ligand; esr1 ... See more keywords