Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.04.071
Abstract: Target selectivity is one of the main challenges in the search for small molecules able to act as effective and non-toxic anticancer and/or antiviral drugs. To achieve this goal, handy, rapid and reliable High Throughput… read more here.
Keywords: conformation selective; pore glass; high throughput; selective quadruplex ... See more keywords
Conformation-Selective Self-Assembly of Pd6 Trifacial Molecular Barrels Using a Tetrapyridyl Ligand.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c01081
Abstract: A conformationally flexible tetrapyridyl ligand L was assembled separately with three cis-blocked 90° PdII acceptors (M1, M2, and M3) containing different blocking diamines. Surprisingly, different conformations of the donor L were arrested by the acceptors… read more here.
Keywords: self assembly; assembly pd6; ligand; selective self ... See more keywords
Development of conformation-selective antibodies targeting human SLC15A4
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62759-x
Abstract: SLC15A4, an endolysosomal solute carrier family transporter, plays a critical role in TLR7/8/9-induced immune responses through assembling a complex with the downstream adaptor TASL in a conformation-dependent manner. Despite its close functional association and promising… read more here.
Keywords: human slc15a4; selective antibodies; conformation; development ... See more keywords
Novel conformation‐selective alpha‐synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2017 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12402
Abstract: The aim of this study was to test the hypothesis that different conformations of misfolded α‐synuclein (α‐syn) are present in Parkinson's disease (PD) brain. read more here.
Keywords: novel conformation; parkinson disease; conformation selective; pathology ... See more keywords