Rational Approach to Optimizing Conformation-Switching Aptamers for Biosensing Applications
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DOI: 10.1021/acssensors.3c02004
Abstract: The utilization of structure-switching aptamers (SSAs) has enabled the development of novel sensing platforms for the sensitive and continuous detection of molecules. De novo development of SSAs, however, is complex and laborious. Here we describe… read more here.
Keywords: switching aptamers; conformation switching; rational approach; approach optimizing ... See more keywords
Conformation switching of single native proteins revealed by nanomechanical probing without a pulling force.
Sign Up to like & getrecommendations! Published in 2019 at "Nanoscale"
DOI: 10.1039/c9nr01448a
Abstract: Protein conformational changes are essential to biological function, and the heterogeneous nature of the corresponding protein states provokes an interest to measure conformational changes at the single molecule level. Here we demonstrate that conformational changes… read more here.
Keywords: protein; native proteins; single native; conformation switching ... See more keywords