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   Articles with "conformational changes" as a keyword



Reagentless detection of staphylococcal enterotoxin B via electrochemical interrogation of conformational changes.

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recommendations! Published in 2022 at "Chirality"

DOI: 10.1002/chir.23481

Abstract: An electrochemical biosensor for staphylococcal enterotoxin B (SEB) detection has been designed on the basis of electrochemical interrogation of conformational changes. Ferrocene-labeled hairpin probe (Fc-HP) and SEB aptamer are introduced for the construction of the… read more here.

Keywords: staphylococcal enterotoxin; conformational changes; detection; interrogation conformational ... See more keywords

When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists

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recommendations! Published in 2022 at "ChemMedChem"

DOI: 10.1002/cmdc.202200556

Abstract: Farnesoid X receptor (FXR) is a nuclear receptor with an essential role in regulating bile acid synthesis and cholesterol homeostasis. FXR activation by agonists is explained by an αAF‐2‐trapping mechanism; however, antagonism mechanisms are diverse.… read more here.

Keywords: changes fxr; two become; conformational changes; fxr rxr ... See more keywords

Ceftriaxone induces glial EAAT‐2 promotor region via NF‐kB conformational changes: An interaction analysis using HADDOCK

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recommendations! Published in 2023 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.30370

Abstract: Excitotoxicity, depletion of energy metabolites, and ionic imbalance are the major factors involved in neurodegeneration mediated through excitatory amino acid transporter‐2 (EAAT‐2) dysfunction in ischemic insult. Recent studies have revealed that ceftriaxone expresses EAAT‐2 via… read more here.

Keywords: interaction; dna; energy; conformational changes ... See more keywords

HBsAg mutations related to occult hepatitis B virus infection in HIV‐positive patients result in a reduced secretion and conformational changes of HBsAg

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recommendations! Published in 2017 at "Journal of Medical Virology"

DOI: 10.1002/jmv.24623

Abstract: Background: Occult hepatitis B infection (OBI) is a frequent finding in human immunodeficiency virus (HIV)‐infected patients. While several related mutations in the hepatitis B virus (HBV) genome have been reported, their distinct impact on HBsAg… read more here.

Keywords: hiv; occult hepatitis; conformational changes; hepatitis virus ... See more keywords

Protein‐mediated electroporation: Pore formation in a calcium voltage‐sensing domain induced by positive and negative nanosecond pulsed electric fields

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recommendations! Published in 2025 at "Protein Science"

DOI: 10.1002/pro.70285

Abstract: In this work, we investigate the conformational changes induced by a positive and negative nanosecond pulsed electric field (nsPEF) on the voltage‐sensing domain (VSD) of a voltage‐gated calcium channel. These conformational changes play a critical… read more here.

Keywords: positive negative; induced positive; voltage; conformational changes ... See more keywords

Conformational change of the extracellular parts of the CFTR protein during channel gating

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recommendations! Published in 2018 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-018-2777-0

Abstract: Cystic fibrosis can be treated by potentiators, drugs that interact directly with the cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel to increase its open probability. These substances likely target key conformational changes occurring during… read more here.

Keywords: extracellular parts; cftr protein; parts cftr; conformational changes ... See more keywords
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Using modern approaches to sedimentation velocity to detect conformational changes in proteins

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recommendations! Published in 2020 at "European Biophysics Journal"

DOI: 10.1007/s00249-020-01453-w

Abstract: It has been known for decades that proteins undergo conformational changes in response to binding ligands. Such changes are usually accompanied by a loss of entropy by the protein, and thus conformational changes are integral… read more here.

Keywords: using modern; sedimentation velocity; modern approaches; conformational changes ... See more keywords
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The study of conformational changes in photosystem II during a charge separation

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recommendations! Published in 2020 at "Journal of Molecular Modeling"

DOI: 10.1007/s00894-020-4332-9

Abstract: Photosystem II (PSII) is a multi-subunit pigment-protein complex and is one of several protein assemblies that function cooperatively in photosynthesis in plants and cyanobacteria. As more structural data on PSII become available, new questions arise… read more here.

Keywords: charge; charge separation; changes photosystem; study conformational ... See more keywords

Conformational changes of surfactant protein B due to the alveolar air/liquid interface using molecular dynamics

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recommendations! Published in 2025 at "Journal of Molecular Modeling"

DOI: 10.1007/s00894-025-06585-4

Abstract: Surfactant Protein B (SP-B) is a critically important component of pulmonary surfactant (PS), responsible for much of the lipid restructuring activity necessary to maintain proper respiratory function. Despite its functional and biological importance, there is… read more here.

Keywords: surfactant protein; changes surfactant; protein; molecular dynamics ... See more keywords

Exploring Ligand-Binding Kinetics in the S2 Site of MhsT by Atomistic Simulations and Markov Models

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.711

Abstract: Neurotransmitter:Sodium Symporters (NSS) terminate neurotransmission through sodium-driven reuptake of cognate neurotransmitters, and traverse between outward-open and inward-open states. NSS include serotonin and dopamine transporters, which are targets for antidepressants and abused psychostimulants. Crystallographically, whereas both… read more here.

Keywords: ligand binding; binding kinetics; site; conformational changes ... See more keywords

Functional and conformational changes to soy proteins accompanying anthocyanins: Focus on covalent and non-covalent interactions.

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recommendations! Published in 2018 at "Food chemistry"

DOI: 10.1016/j.foodchem.2017.11.090

Abstract: The present study was aimed to evaluate the interaction between anthocyanins from black rice and soybean protein isolate (SPI) via non-covalent and covalent bindings and the impact of these interactions on the functional and conformational… read more here.

Keywords: covalent; functional conformational; interactions functional; conformational changes ... See more keywords