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Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.

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0 Published in 2021 at "Nucleic acids research"

DOI: 10.1093/nar/gkaa1249

Abstract: We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (Tm) of PNA+DNA duplexes by approximately… read more here.

Keywords: nucleic acids; dna duplexes; peptide nucleic; dna ... See more keywords