The use of Surface Plasmon Resonance to study the interactions of proteins involved in conformational diseases: experimental approaches for new therapeutical perspectives.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230116162646
Abstract: In recent years, the scientific community has been trying to tackle different diseases by using unifying and holistic approaches based on the concept that it is possible to target apparently very different diseases under a… read more here.
Keywords: plasmon resonance; surface plasmon; conformational diseases; experimental approaches ... See more keywords
Pharmacological Chaperones and Protein Conformational Diseases: Approaches of Computational Structural Biology
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DOI: 10.3390/ijms24065819
Abstract: Whenever a protein fails to fold into its native structure, a profound detrimental effect is likely to occur, and a disease is often developed. Protein conformational disorders arise when proteins adopt abnormal conformations due to… read more here.
Keywords: conformational diseases; structural biology; pharmacological chaperones; computational structural ... See more keywords
Exploiting Caenorhabditis elegans to discover human gut microbiota-mediated intervention strategies in protein conformational diseases
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.335788
Abstract: Age-dependent protein-conformational diseases (PCDs), such as Alzheimer ’s disease (AD), Parkinson’s disease (PD), or amyotrophic lateral sclerosis (ALS), are characterized by misfolding and aggregation of metastable proteins present within the proteome of the affected individual.… read more here.
Keywords: conformational diseases; disease; host proteostasis; prevotella ... See more keywords