Hybrid thermophilic/mesophilic enzymes reveal a role for conformational disorder in regulation of bacterial Enzyme I.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.05.024
Abstract: Conformational disorder is emerging as an important feature of biopolymers, regulating a vast array of cellular functions, including signaling, phase separation, and enzyme catalysis. Here we combine NMR, crystallography, computer simulations, protein engineering, and functional… read more here.
Keywords: hybrid thermophilic; bacterial enzyme; enzyme; conformational disorder ... See more keywords
Triplets with a Twist: Ultrafast Intersystem Crossing in a Series of Electron Acceptor Materials Driven by Conformational Disorder.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12605
Abstract: Control over the populations of singlet and triplet excitons is key to organic semiconductor technologies. In different contexts, triplets can represent an energy loss pathway that must be managed (i.e., solar cells, light-emitting diodes, and… read more here.
Keywords: series; intersystem crossing; electron acceptor; conformational disorder ... See more keywords
Measuring local conformations and conformational disorder of (Cy3)2 dimer labeled DNA fork junctions using absorbance, circular dichroism and two-dimensional fluorescence spectroscopy.
Sign Up to like & getrecommendations! Published in 2019 at "Faraday discussions"
DOI: 10.1039/c8fd00245b
Abstract: The sugar-phosphate backbone of DNA near single-stranded (ss)-double-stranded (ds) junctions likely fluctuates within a broad distribution of conformations to permit the proper binding of genome regulatory proteins that function at these sites. In this work… read more here.
Keywords: spectroscopy; dna fork; fork junctions; conformational disorder ... See more keywords
Single-exponential solid-state delayed fluorescence decay in TADF compounds with minimized conformational disorder
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Materials Chemistry C"
DOI: 10.1039/d0tc05503d
Abstract: Thermally activated delayed fluorescence (TADF) compounds with rapid triplet upconversion in solutions frequently yield drastically lowered upconversion rates in solid hosts due to the conformational disorder, resulting in prolonged multiexponential TADF decay profiles. The dispersion… read more here.
Keywords: solid state; tadf; conformational disorder; fluorescence ... See more keywords
Studies of Local DNA Backbone Conformation and Conformational Disorder Using Site-Specific Exciton-Coupled Dimer Probe Spectroscopy.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of physical chemistry"
DOI: 10.1146/annurev-physchem-090419-041204
Abstract: The processes of genome expression, regulation, and repair require direct interactions between proteins and DNA at specific sites located at and near single-stranded-double-stranded DNA (ssDNA-dsDNA) junctions. Here, we review the application of recently developed spectroscopic… read more here.
Keywords: dna; spectroscopy; chemistry; conformational disorder ... See more keywords
Conformational Disorder Analysis of the Conditionally Disordered Protein CP12 from Arabidopsis thaliana in Its Different Redox States
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119308
Abstract: CP12 is a redox-dependent conditionally disordered protein universally distributed in oxygenic photosynthetic organisms. It is primarily known as a light-dependent redox switch regulating the reductive step of the metabolic phase of photosynthesis. In the present… read more here.
Keywords: conditionally disordered; conformational disorder; redox; analysis ... See more keywords