Mutational and Environmental Effects on the Dynamic Conformational Distributions of Lys48-Linked Ubiquitin Chains
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DOI: 10.3390/ijms24076075
Abstract: In multidomain proteins, individual domains connected by flexible linkers are dynamically rearranged upon ligand binding and sensing changes in environmental factors, such as pH and temperature. Here, we characterize dynamic domain rearrangements of Lys48-linked ubiquitin… read more here.
Keywords: lys48 linked; linked ubiquitin; conformational distributions; unit ... See more keywords
Conformational distributions of isolated myosin motor domains encode their mechanochemical properties
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DOI: 10.7554/elife.55132
Abstract: Myosin motor domains perform an extraordinary diversity of biological functions despite sharing a common mechanochemical cycle. Motors are adapted to their function, in part, by tuning the thermodynamics and kinetics of steps in this cycle.… read more here.
Keywords: isolated myosin; distributions isolated; myosin motor; motor domains ... See more keywords