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Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30305
Abstract: The mutations at the hotspot region of K‐Ras result in the progression of cancer types. Our study aimed to explore the small molecule inhibitors against the G13D mutant K‐Ras model with anti‐cancerous activity from food…
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Keywords:
potential inhibitors;
identification potential;
driven cancers;
conformational dynamics ... See more keywords
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Published in 2017 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-017-8237-1
Abstract: N-acetylglutamate kinase (NAGK) catalyzes the phosphorylation of N-acetylglutamate. In many bacteria, NAGK catalysis is the rate controlling step in the L-arginine biosynthesis pathway from glutamate to L-arginine and is allosterically inhibited by L-arginine. Many data…
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Keywords:
conformational dynamics;
acetylglutamate kinase;
play important;
dynamics play ... See more keywords
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Published in 2017 at "Journal of Biomolecular NMR"
DOI: 10.1007/s10858-017-0099-4
Abstract: Although Chemical Exchange Saturation Transfer (CEST) type NMR experiments have been used to study chemical exchange processes in molecules since the early 1960s, there has been renewed interest in the past several years in using…
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Keywords:
methodology;
conformational dynamics;
chemical exchange;
exchange ... See more keywords
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Published in 2019 at "Biophysical Reviews"
DOI: 10.1007/s12551-019-00539-w
Abstract: G protein–coupled receptors (GPCRs) function as receptors for various neurotransmitters, hormones, cytokines, and metabolites. GPCR ligands impart differing degrees of signaling in the G protein and arrestin pathways, in phenomena called biased signaling, and each…
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Keywords:
biased signaling;
conformational dynamics;
protein coupled;
coupled receptors ... See more keywords
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Published in 2021 at "Biophysical reviews"
DOI: 10.1007/s12551-021-00858-x
Abstract: Intrinsically disordered proteins (IDPs) are proteins that lack rigid 3D structure but exist as conformational ensembles. Because of their structural plasticity, they can interact with multiple partners. The protein interactions between IDPs and their partners…
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Keywords:
protein conformational;
noise;
conformational dynamics;
phenotypic switching ... See more keywords
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Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1354
Abstract: (Wang et al, 2016). We have now systematically examined conformational dynamics of this region in different ionic conditions using smFRET. Our results show that this region undergoes significant conformational dynamics, between well separated structural states…
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Keywords:
conformational dynamics;
probing gating;
gating kv10;
mts reagents ... See more keywords
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Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2018.10.044
Abstract: Abstract In aqueous medium, [Pr(H 2 O)(DOTA)] − ( I ) undergo a intramolecular interconversion between two conformers (here DOTA = 1, 4, 7, 10-tetraaza-1, 4, 7, 10-tetrakis (carboxymethyl)cyclododecan; n = 0, 1, 2). Two types of molecular dynamic…
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Keywords:
two types;
dynamics thermo;
sensor properties;
types conformational ... See more keywords
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Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101547
Abstract: Summary Circovirus, comprising one capsid protein, is the smallest nonenveloped virus and induces lymphopenia. Circovirus can be used to explore the cell adhesion mechanism of nonenveloped viruses. We developed a single-molecule fluorescence resonance energy transfer…
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Keywords:
conformational dynamics;
circovirus;
receptor;
cell surface ... See more keywords
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Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2021.103575
Abstract: Summary I-motifs are noncanonical four-stranded DNA structures formed by C-rich sequences at acidic environment with critical biofunctions. The particular pH sensitivity has inspired the development of i-motifs as pH sensors and DNA motors in nanotechnology.…
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Keywords:
dna;
acidic environment;
conformational dynamics;
remodeling conformational ... See more keywords
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Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.166764
Abstract: Apical sodium-dependent bile acid transporter (ASBT) catalyses uphill transport of bile acids using the electrochemical gradient of Na+ as the driving force. The crystal structures of two bacterial homologues ASBTNM and ASBTYf have previously been…
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Keywords:
bile acid;
acid transporter;
crystal structures;
conformational dynamics ... See more keywords
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Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167356
Abstract: The crucial function of neurotransmitter:sodium symporters (NSS) in facilitating the reuptake of neurotransmitters into neuronal cells makes them attractive drug targets for treating multiple mental diseases. Due to the challenges in working with eukaryotic NSS…
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Keywords:
conformational dynamics;
temperature;
slow unfolding;
leut ... See more keywords