Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR
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DOI: 10.1038/s41467-020-19005-3
Abstract: The potassium ion (K+) channel plays a fundamental role in controlling K+ permeation across the cell membrane and regulating cellular excitabilities. Mutations in the transmembrane pore reportedly affect the gating transitions of K+ channels, and… read more here.
Keywords: equilibrium shift; shift underlies; equilibrium; conformational equilibrium ... See more keywords
DNA conformational equilibrium enables continuous changing of curvatures.
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DOI: 10.1039/d2nr05404c
Abstract: Assembly of complex structures from a small set of tiles is a common theme in biology. For example, many copies of identical proteins make up polyhedron-shaped, viral capsids and tubulin can make long microtubules. This… read more here.
Keywords: enables continuous; dna; equilibrium enables; conformational equilibrium ... See more keywords
Anionic Phospholipids Shift the Conformational Equilibrium of the Selectivity Filter in the KcsA Channel to the Conductive Conformation: Predicted Consequences on Inactivation
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DOI: 10.3390/biomedicines11051376
Abstract: Here, we report an allosteric effect of an anionic phospholipid on a model K+ channel, KcsA. The anionic lipid in mixed detergent–lipid micelles specifically induces a change in the conformational equilibrium of the channel selectivity… read more here.
Keywords: kcsa; conformational equilibrium; anionic lipid; selectivity filter ... See more keywords