Kinetic and Conformational Insights into Islet Amyloid Polypeptide Self-Assembly Using a Biarsenical Fluorogenic Probe.
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DOI: 10.1021/acs.bioconjchem.7b00827
Abstract: Amyloid fibril formation and tissue deposition are associated with many diseases. Studies have shown that prefibrillar intermediates, such as oligomers, are the most toxic proteospecies of the amyloidogenic cascade. Thus, understanding the mechanisms of formation… read more here.
Keywords: self assembly; cys; fluorogenic probe; kinetic conformational ... See more keywords