LAUSR

Analytical and functional aspects of protein-ligand interactions: Beyond induced fit and conformational selection.

Sign Up to like & get
recommendations!
0 Published in 2021 at "Archives of biochemistry and biophysics"

DOI: 10.1016/j.abb.2021.109064

Abstract: Ligand-dependent changes in protein conformation are foundational to biology. Historical mechanistic models for substrate-specific proteins are induced fit (IF) and conformational selection (CS), which invoke a change in protein conformation after ligand binds or before… read more here.

Keywords: protein; conformational selection; analytical functional; induced fit ... See more keywords

Conformational selection and induced fit as a useful framework for molecular motor mechanisms.

Sign Up to like & get
recommendations!
0 Published in 2017 at "Biophysical chemistry"

DOI: 10.1016/j.bpc.2017.01.004

Abstract: The linkage between macromolecular binding and conformational change that is ubiquitous in biological molecules can be understood in the context of the mechanisms of conformational selection and induced fit. Here, we explore mappings between these… read more here.

Keywords: conformational selection; fit useful; selection induced; mechanisms conformational ... See more keywords

NMR Studies of Conformational Selection of hnRNP H on RNA Splicing

Sign Up to like & get
recommendations!
1 Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.1877

Abstract: Modularity provides proteins versatility in regulating many cellular processes. The RNA Recognition Motif (RRM) is a common protein family that adopts modularity to facilitate its biological activity. hnRNP H contains three RRMs that play important… read more here.

Keywords: conformational selection; hnrnp; form; closed form ... See more keywords

Big Data analytics for improved prediction of ligand binding and conformational selection

Sign Up to like & get
recommendations!
2 Published in 2023 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.953984

Abstract: This research introduces new machine learning and deep learning approaches, collectively referred to as Big Data analytics techniques that are unique to address the protein conformational selection mechanism for protein:ligands complexes. The novel Big Data… read more here.

Keywords: conformational selection; big data; prediction; data analytics ... See more keywords

Using Big Data Analytics to “Back Engineer” Protein Conformational Selection Mechanisms

Sign Up to like & get
recommendations!
1 Published in 2022 at "Molecules"

DOI: 10.3390/molecules27082509

Abstract: In the living cells, proteins bind small molecules (or “ligands”) through a “conformational selection” mechanism, where a subset of protein structures are capable of binding the small molecules well while most other protein structures are… read more here.

Keywords: conformational selection; big data; small molecules; protein conformations ... See more keywords