Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor
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DOI: 10.1038/s42003-018-0134-3
Abstract: Discovery of biased ligands and receptor mutants allows characterization of G-protein- and β-arrestin-mediated signaling mechanisms of G-protein-coupled receptors (GPCRs). However, the structural mechanisms underlying biased agonism remain unclear for many GPCRs. We show that while… read more here.
Keywords: protein; biased agonism; conformational signatures; protein coupled ... See more keywords