Conformational states of TNFR1 as a molecular switch for receptor function
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3829
Abstract: Tumor necrosis factor receptor 1 (TNFR1) is a transmembrane receptor that plays a key role in the regulation of the inflammatory pathway. While inhibition of TNFR1 has been the focus of many studies for the… read more here.
Keywords: receptor; receptor function; conformational states; molecular switch ... See more keywords
FRET studies of various conformational states adopted by transthyretin
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2533-x
Abstract: Transthyretin (TTR) is an extracellular protein able to deposit into well-defined protein aggregates called amyloid, in pathological conditions known as senile systemic amyloidosis, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and leptomeningeal amyloidosis. At least three… read more here.
Keywords: state; fret efficiency; fret studies; conformational states ... See more keywords
Biased allosteric modulation of formyl peptide receptor 2 leads to distinct receptor conformational states for pro- and anti-inflammatory signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105117
Abstract: BACKGROUND AND PURPOSE Formyl peptide receptor 2 (FPR2) is a Class A G protein-coupled receptor (GPCR) that interacts with multiple ligands and transduces both proinflammatory and anti-inflammatory signals. These ligands include weak agonists and modulators… read more here.
Keywords: anti inflammatory; conformational states; receptor; peptide receptor ... See more keywords
Equilibria between conformational states of the Ras oncogene protein revealed by high pressure crystallography
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc05488k
Abstract: In this work, we experimentally investigate the allosteric transitions between conformational states on the Ras oncogene protein using high pressure crystallography. Ras protein is a small GTPase involved in central regulatory processes occurring in multiple… read more here.
Keywords: conformational states; pressure; ras oncogene; crystallography ... See more keywords
Conformational states dynamically populated by a kinase determine its function
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abc2754
Abstract: A moving target Abl kinase is an important signaling protein that is dysregulated in leukemia and other cancers and is the target of inhibitors such as imatinib. Like other kinases, Abl kinase is dynamic, and… read more here.
Keywords: inactive states; abl kinase; kinase; conformational states ... See more keywords
The HIV Env Glycoprotein Conformational States on Cells and Viruses
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DOI: 10.1128/mbio.01825-21
Abstract: The HIV Env glycoprotein is the surface glycoprotein responsible for viral entry into CD4+ immune cells. During infection, Env also serves as a primary target for antibody responses, which are robust but unable to control… read more here.
Keywords: env glycoprotein; cell; conformational states; env ... See more keywords
Structure of the human activated spliceosome in three conformational states.
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.2210/pdb5z58/pdb
Abstract: During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is converted into the activated spliceosome (Bact complex), which has a well-formed active site but cannot proceed to the branching reaction. Here, we present… read more here.
Keywords: conformational states; bact complex; activated spliceosome; structure ... See more keywords
Probing the Conformational States of Thimet Oligopeptidase in Solution
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137297
Abstract: Thimet oligopeptidase (TOP) is a metallopeptidase involved in the metabolism of oligopeptides inside and outside cells of various tissues. It has been proposed that substrate or inhibitor binding in the TOP active site induces a… read more here.
Keywords: thimet oligopeptidase; probing conformational; conformational states; oligopeptidase solution ... See more keywords
Towards Probing Conformational States of Y2 Receptor Using Hyperpolarized 129Xe NMR
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031424
Abstract: G protein-coupled receptors can adopt many different conformational states, each of them exhibiting different restraints towards downstream signaling pathways. One promising strategy to identify and quantify this conformational landscape is to introduce a cysteine at… read more here.
Keywords: probing conformational; conformational states; towards probing; states receptor ... See more keywords
Sampling alternative conformational states of transporters and receptors with AlphaFold2
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.75751
Abstract: Equilibrium fluctuations and triggered conformational changes often underlie the functional cycles of membrane proteins. For example, transporters mediate the passage of molecules across cell membranes by alternating between inward- and outward-facing states, while receptors undergo… read more here.
Keywords: states transporters; conformational states; transporters receptors; sampling alternative ... See more keywords