The pressure and temperature perturbation approach reveals a whole variety of conformational substates of amyloidogenic hIAPP monitored by 2D NMR spectroscopy.
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DOI: 10.1016/j.bpc.2019.106239
Abstract: The intrinsically disordered human islet amyloid polypeptide (hIAPP) is a 37 amino acid peptide hormone that is secreted by pancreatic beta cells along with glucagon and insulin. The glucose metabolism of humans is regulated by… read more here.
Keywords: conformational substates; spectroscopy; hiapp; self assembly ... See more keywords