The C-terminal domain conformational switch revealed by the crystal structure of malyl-CoA lyase from Roseiflexus castenholzii.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.010
Abstract: Malyl-coenzyme A lyase (MCL) is a carbon-carbon bond lyase that catalyzes the reversible cleavage of coenzyme A (CoA) thioesters in multiple carbon metabolic pathways. This enzyme contains a CitE-like TIM barrel and an additional C-terminal… read more here.
Keywords: crystal structure; terminal domain; roseiflexus castenholzii; conformational switch ... See more keywords
Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Redox Biology"
DOI: 10.1016/j.redox.2022.102290
Abstract: Endothelial dysfunction is the initial process of atherosclerosis. Heat shock protein 90 (Hsp90), as a molecular chaperone, plays a crucial role in various cardiovascular diseases. Hsp90 function is regulated by S-nitrosylation (SNO). However, the precise… read more here.
Keywords: conformational switch; hsp90; atherosclerosis; sno hsp90 ... See more keywords
A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16583-z
Abstract: Tyrosine kinase inhibitors (TKIs) are a major class of drug utilised in the clinic. During transit to their cognate kinases, TKIs will encounter different pH environments that could have a major influence on TKI structure.… read more here.
Keywords: switch tyrosine; conformational switch; spectroscopy; tyrosine kinase ... See more keywords
Conformational switch in the crystal states of a calix[4]arene
Sign Up to like & getrecommendations! Published in 2021 at "CrystEngComm"
DOI: 10.1039/d0ce01704c
Abstract: We report the discovery of a novel metastable polymorph of a propyloxy substituted calix[4]arene molecule which undergoes two distinct transformations to form different conformers and packing arrangements. The first transition was found as a reversible… read more here.
Keywords: crystal; calix arene; crystal states; conformational switch ... See more keywords
An α-ketoglutarate conformational switch controls iron accessibility, activation, and substrate selection of the human FTO protein
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2404457121
Abstract: Significance FTO is an RNA demethylase of the Alkb family of dioxygenases involved in regulation of gene expression and development of metabolic diseases such as obesity and cancer. Given its central role, extensive effort has… read more here.
Keywords: conformational switch; activation substrate; fto; substrate ... See more keywords
H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1299
Abstract: Abstract As an environment-dependent pleiotropic gene regulator in Gram-negative bacteria, the H-NS protein is crucial for adaptation and toxicity control of human pathogens such as Salmonella, Vibrio cholerae or enterohaemorrhagic Escherichia coli. Changes in temperature… read more here.
Keywords: uses autoinhibitory; switch environment; autoinhibitory conformational; gene ... See more keywords