The C-terminal domain conformational switch revealed by the crystal structure of malyl-CoA lyase from Roseiflexus castenholzii.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.010
Abstract: Malyl-coenzyme A lyase (MCL) is a carbon-carbon bond lyase that catalyzes the reversible cleavage of coenzyme A (CoA) thioesters in multiple carbon metabolic pathways. This enzyme contains a CitE-like TIM barrel and an additional C-terminal… read more here.
Keywords: crystal structure; terminal domain; roseiflexus castenholzii; conformational switch ... See more keywords
Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Redox Biology"
DOI: 10.1016/j.redox.2022.102290
Abstract: Endothelial dysfunction is the initial process of atherosclerosis. Heat shock protein 90 (Hsp90), as a molecular chaperone, plays a crucial role in various cardiovascular diseases. Hsp90 function is regulated by S-nitrosylation (SNO). However, the precise… read more here.
Keywords: conformational switch; hsp90; atherosclerosis; sno hsp90 ... See more keywords
A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16583-z
Abstract: Tyrosine kinase inhibitors (TKIs) are a major class of drug utilised in the clinic. During transit to their cognate kinases, TKIs will encounter different pH environments that could have a major influence on TKI structure.… read more here.
Keywords: switch tyrosine; conformational switch; spectroscopy; tyrosine kinase ... See more keywords
Conformational switch in the crystal states of a calix[4]arene
Sign Up to like & getrecommendations! Published in 2021 at "CrystEngComm"
DOI: 10.1039/d0ce01704c
Abstract: We report the discovery of a novel metastable polymorph of a propyloxy substituted calix[4]arene molecule which undergoes two distinct transformations to form different conformers and packing arrangements. The first transition was found as a reversible… read more here.
Keywords: crystal; calix arene; crystal states; conformational switch ... See more keywords
H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1299
Abstract: Abstract As an environment-dependent pleiotropic gene regulator in Gram-negative bacteria, the H-NS protein is crucial for adaptation and toxicity control of human pathogens such as Salmonella, Vibrio cholerae or enterohaemorrhagic Escherichia coli. Changes in temperature… read more here.
Keywords: uses autoinhibitory; switch environment; autoinhibitory conformational; gene ... See more keywords