Conformational transition and gelation of κ-carrageenan in electrostatic complexation with β-lactoglobulin aggregates
Sign Up to like & getrecommendations! Published in 2021 at "Food Hydrocolloids"
DOI: 10.1016/j.foodhyd.2021.106764
Abstract: Abstract The goal of this study was to evaluate the impact of electrostatic complexation with three different β-lactoglobulin aggregates on the conformational transition and gelation of κ-carrageenan (κ-car). We prepared native granular β-lactoglobulin (NGBLG), nanoparticle… read more here.
Keywords: lactoglobulin; conformational transition; electrostatic complexation; transition ... See more keywords
p38α Kinase Auto-Activation through Its Conformational Transition Induced by Tyr323 Phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00236
Abstract: p38α is a key serine/threonine kinase that can enable atypical auto-activation through Zap70 phosphorylation and initiate T cell receptor signaling. The auto-activation plays an important role in autoimmune diseases. Although the classical activation mechanism of… read more here.
Keywords: conformational transition; auto activation; phosphorylation; p38 ... See more keywords
The Physical Driving Forces of Conformational Transition for TTR91-96 with Proline Mutations
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.4c01464
Abstract: Pathological aggregation of essentially dissociated Transthyretin (TTR) monomer proteins, driven by misfolding and self-interaction, is associated with Transthyretin amyloidosis (ATTR) disease. The TTR monomer proteins consist of several fragments that tend to self-aggregate. Recent experimental… read more here.
Keywords: ttr91; physical driving; transition; aggregation ... See more keywords
Membrane lipid homeostasis dually regulates conformational transition of phosphoethanolamine transferase EptA
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-54607-1
Abstract: The phosphoethanolamine transferase EptA utilizes phosphatidylethanolamine (PE) in the bacterial cell membrane to modify the structure of lipopolysaccharide, thereby conferring antimicrobial resistance on Gram-negative pathogens. Previous studies have indicated that excessive consumption of PE can… read more here.
Keywords: epta; phosphoethanolamine transferase; membrane lipid; conformational transition ... See more keywords
Molecular conformational transition of chiral conjugated enantiomers dominated by Wallach's rule
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Materials Chemistry C"
DOI: 10.1039/d1tc00978h
Abstract: Comparison of racemic and homochiral analogues reveals that the racemic compounds appear to crystallize easily upon external thermal annealing and show more stable morphology. These differences will induce the formation of a planar conformation in… read more here.
Keywords: transition chiral; wallach rule; molecular conformational; wallach ... See more keywords
Conformational transition-induced simultaneous fluorescence enhancement of oxytetracycline and rhodamine B under a single excitation wavelength.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt03305d
Abstract: Since the abuse of antibiotic oxytetracycline (OTC) poses a serious threat to the environment and human health, it is of great importance to develop sensitive fluorescent probes for its rapid and in situ detection. Herein,… read more here.
Keywords: excitation; fluorescence enhancement; single excitation; conformational transition ... See more keywords
Bistricyclic aromatic enes with fast conformational transition for ultrathin piezochromic films.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc01054c
Abstract: New bistricyclic aromatic enes (BAEs) with a faster conformational transition were synthesized to improve the fabrication efficiency of BAE-based piezochromic films. Through ultrathin design, our 5-μm-thick BAE-based films can conform to non-planar surfaces and minimize… read more here.
Keywords: bistricyclic aromatic; aromatic enes; piezochromic films; enes fast ... See more keywords
Edaravone inhibits the conformational transition of amyloid-β42: insights from molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1632225
Abstract: Abstract Previous work has shown that edaravone inhibits fibrillogenesis of amyloid-β protein (Aβ). However, the detailed mechanism by which edaravone inhibits the conformational transition of the Aβ42 monomer is not known at the molecular level.… read more here.
Keywords: edaravone inhibits; transition; molecular dynamics; conformational transition ... See more keywords
Molecular basis for the inhibitory effects of 5-hydroxycyclopenicillone on the conformational transition of Aβ40 monomer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1799863
Abstract: Abstract Previous studies have indicated that 5-hydroxycyclopenicillone (HCP), an active compound derived from marine sponge, could inhibit oligomerization of amyloid β-protein (Aβ). However, the molecular basis for the interaction between HCP and Aβ remains unclear.… read more here.
Keywords: inhibitory effects; molecular basis; hcp; conformational transition ... See more keywords
Electrostatics-Induced Nucleated Conformational Transition of Protein Aggregation.
Sign Up to like & getrecommendations! Published in 2023 at "Physical review letters"
DOI: 10.1103/physrevlett.130.158401
Abstract: Despite the wide existence of protein aggregation in nature and its intimate connection to many human diseases, the underlying mechanism remains unclear. Here, we develop a molecular theory by systematically incorporating the self-consistent field theory… read more here.
Keywords: electrostatics; transition; protein aggregation; conformational transition ... See more keywords
Controlling the Redox Catalytic Activity of a Cyclic Selenide Fused to 18-Crown-6 by the Conformational Transition Induced by Coordination to an Alkali Metal Ion
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083607
Abstract: trans-3,4-Dihydroxyselenolane (DHS), a water-soluble cyclic selenide, exhibits selenoenzyme-like unique redox activities through reversible oxidation to the corresponding selenoxide. Previously, we demonstrated that DHS can be applied as an antioxidant against lipid peroxidation and a radioprotector… read more here.
Keywords: metal ion; redox catalytic; conformational transition; activity ... See more keywords