Computational methods for analyzing conformational variability of macromolecular complexes from cryo-electron microscopy images.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2016.12.011
Abstract: Thanks to latest technical advances in cryo-electron microscopy (cryo-EM), structures of macromolecular complexes (viruses, ribosomes, etc.) are now often obtained at near-atomic resolution. Also, studies of conformational changes of complexes, in connection with their function,… read more here.
Keywords: conformational variability; cryo electron; microscopy; macromolecular complexes ... See more keywords
Effect of Conformational Variability on Seasonable Thermal Stability and Cell Entry of Omicron Variants
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DOI: 10.1021/acsomega.2c08075
Abstract: The Omicron BA.1 variant of SARS-CoV-2 preferentially infects through the cathepsin-mediated endocytic pathway, but the mechanism of cell entry has not been solved yet because BA.4/5 is more fusogenic and more efficiently spread in human… read more here.
Keywords: cell entry; omicron; conformational variability;
Predicting the conformational variability of oncogenic GTP-bound G12D mutated KRas-4B proteins at zwitterionic model cell membranes.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr07622a
Abstract: KRas proteins are the largest family of mutated Ras isoforms, participating in a wide variety of cancers. Due to their importance, large effort is being carried out on drug development by small-molecule inhibitors. However, understanding… read more here.
Keywords: gtp bound; kras proteins; conformational variability; g12d mutated ... See more keywords
Conformational Variability of Amyloid-β and the Morphological Diversity of Its Aggregates
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DOI: 10.3390/molecules27154787
Abstract: Protein folding is the most fundamental and universal example of biomolecular self-organization and is characterized as an intramolecular process. In contrast, amyloidogenic proteins can interact with one another, leading to protein aggregation. The energy landscape… read more here.
Keywords: energy landscape; energy; conformational variability; diversity ... See more keywords