Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor–ligand signaling complex
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DOI: 10.1073/pnas.2308132121
Abstract: Significance Tumor necrosis factor (TNF) is a critical regulator of inflammatory responses against harmful stimuli such as infections. However, excessive amount of TNF can cause autoimmune diseases. Current anti-TNF therapeutics are expensive and can induce… read more here.
Keywords: peptide based; allosteric inhibitor; receptor ligand; conformationally active ... See more keywords