Novel synthetic approach to non-natural conformationally rigid spiro-linked amino acids
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DOI: 10.1007/s11172-019-2452-0
Abstract: Abstract1-Aminospiro[2.3]hexane-1,5-dicarboxylic and 1-ammo-5-(ammomethyl)spiro[2.3]hexane-1-carboxylic acids, which are the conformationally rigid analogues of glutamic acid and lysine, respectively, were synthesized from 3-methylidenecyclobutanecarbonitrile. The synthetic route includes a catalytic [1+2]-cycloaddition of ethyl 2-diazo-2-nitroacetate to a double bond of… read more here.
Keywords: novel synthetic; non natural; spiro; approach non ... See more keywords
Group 13 element containing conformationally rigid "N-E-N" heteroatomic bridged [3.3](2,6)pyridinophanes (E = B, Al).
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DOI: 10.1039/c8cc05154b
Abstract: The first examples of group 13 element containing pyridinophanes have been assembled using heteroatom N-E-N bridges (E = B, Al). The presence of B and Al as acceptor atoms in the bridges and their coordination… read more here.
Keywords: containing conformationally; group element; element containing; conformationally rigid ... See more keywords