PEG‐Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202107852
Abstract: Ribonucleic acid (RNA) therapeutics are an emerging class of drugs. RNA aptamers are of significant therapeutic and clinical interest because their activity can be easily reversed in vivo—a useful feature that is difficult to achieve… read more here.
Keywords: polymer; rna; rna aptamer; peg ... See more keywords
Covalent Affibody‐Molecular Glue Drug Conjugate Nanoagent for Proximity‐Enabled Reactive Therapeutics
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202412273
Abstract: Sulfur‐fluoride exchange (SuFEx) reaction is an emerging class of click chemistry reaction. Owing to its efficient reactivity under physiological conditions, SuFEx reaction is used to construct covalent protein drugs. Herein, a covalent affibody‐molecular glue drug… read more here.
Keywords: glue drug; molecular glue; 342 36fsy; zher2 342 ... See more keywords
Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202502270
Abstract: Immune‐stimulating antibody conjugate (ISACs) incorporating STING agonists as payloads leverage both the targeting capability of the Fab region and the Fc region‐mediated tumor antigen‐dependent immune activation. Herein, a novel class of ISACs is reported, generated… read more here.
Keywords: sting agonist; activation; tumor; quaternary ammonium ... See more keywords
A Conjugate of an Anti‐Epidermal Growth Factor Receptor (EGFR) VHH and a Cell‐Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700444
Abstract: Overexpression of (mutated) receptor tyrosine kinases is a characteristic of many aggressive tumors, and induction of receptor uptake has long been recognized as a therapeutic modality. A conjugate of a synthetically produced cell‐penetrating peptide (CPP),… read more here.
Keywords: conjugate; penetrating peptide; cell penetrating; activation ... See more keywords
Unveiling the Potential of a New β‐Cyclodextrin‐Suxibuzone Conjugate in Proteasome Regulation
Sign Up to like & getrecommendations! Published in 2025 at "Chemmedchem"
DOI: 10.1002/cmdc.202500401
Abstract: The proteasome is a central component of the cellular machinery responsible for degrading misfolded or damaged proteins, thereby maintaining protein homeostasis. Dysregulation of proteasome activity has been implicated in various diseases, including neurodegenerative disorders and… read more here.
Keywords: proteasome; suxibuzone; new cyclodextrin; conjugate ... See more keywords
Assessing stimulus preference using response force in a conjugate preparation: A replication and extension.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the experimental analysis of behavior"
DOI: 10.1002/jeab.926
Abstract: The current study examined 98 participants' preferences for five pictorial stimuli. The researchers used a verbal multiple-stimulus-without-replacement (VMSWO) preference assessment with each participant to identify high-preference and low-preference pictorial stimuli. Next, participants viewed each pictorial… read more here.
Keywords: preference; force; response; stimulus preference ... See more keywords
PEGylated Dendritic Polyglycerol Conjugate Delivers Doxorubicin to the Parasitophorous Vacuole in Leishmania infantum Infections.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201700098
Abstract: Most drugs against visceral leishmaniasis must be administered parenterally. A controlled drug release at the target site can improve the efficacy and toxicity of antileishmanial drugs in clinical use. Amastigotes live and grow inside the… read more here.
Keywords: pegylated dendritic; conjugate; dendritic polyglycerol; parasitophorous vacuole ... See more keywords
Performance of a Flow-Through Enzyme Reactor Prepared from a Silica Monolith and an α-Poly(D-Lysine)-Enzyme Conjugate.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200465
Abstract: Horseradish peroxidase (HRP) is covalently bound in aqueous solution to polycationic α-poly(D-lysine) chains of approximately 1000 repeating units length, PDL, via a bis-aryl hydrazone bond (BAH). Under the experimental conditions used, about 15 HRP molecules… read more here.
Keywords: hrp; enzyme reactor; conjugate; monolith ... See more keywords
Full utilization of conjugate symmetry: combining virtual conjugate coil reconstruction with partial Fourier imaging for g‐factor reduction in accelerated MRI
Sign Up to like & getrecommendations! Published in 2019 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.27799
Abstract: In this study we propose a method to combine the parallel virtual conjugate coil (VCC) reconstruction with partial Fourier (PF) acquisition to improve reconstruction conditioning and reduce noise amplification in accelerated MRI where PF is… read more here.
Keywords: reconstruction; virtual conjugate; conjugate; reconstruction partial ... See more keywords
(Para-)Holomorphic and Conjugate Connections on (Para-)Hermitian and (Para-)Kähler Manifolds
Sign Up to like & getrecommendations! Published in 2019 at "Results in Mathematics"
DOI: 10.1007/s00025-019-1071-2
Abstract: We investigate how an affine connection $$\nabla $$ that generally admits torsion interacts with both g and L on an almost (para-)Hermitian manifold $$(\mathfrak {M},g,L)$$, where L denotes either an almost complex structure J with… read more here.
Keywords: torsion; nabla nabla; para hermitian; conjugate ... See more keywords
Preclinical development of the quadrivalent meningococcal (ACYW) tetanus toxoid conjugate vaccine, MenQuadfi®
Sign Up to like & getrecommendations! Published in 2022 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-022-10050-2
Abstract: Bacterial capsular polysaccharide vaccines are generally poorly immunogenic in infants and older adults. The immunogenicity of capsular polysaccharide vaccines can be improved by conjugating them to immunogenic carrier proteins. One of the most recently licensed… read more here.
Keywords: tetanus toxoid; development; conjugate; conjugate vaccine ... See more keywords