PEG‐Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202107852
Abstract: Ribonucleic acid (RNA) therapeutics are an emerging class of drugs. RNA aptamers are of significant therapeutic and clinical interest because their activity can be easily reversed in vivo—a useful feature that is difficult to achieve… read more here.
Keywords: polymer; rna; rna aptamer; peg ... See more keywords
A Conjugate of an Anti‐Epidermal Growth Factor Receptor (EGFR) VHH and a Cell‐Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700444
Abstract: Overexpression of (mutated) receptor tyrosine kinases is a characteristic of many aggressive tumors, and induction of receptor uptake has long been recognized as a therapeutic modality. A conjugate of a synthetically produced cell‐penetrating peptide (CPP),… read more here.
Keywords: conjugate; penetrating peptide; cell penetrating; activation ... See more keywords
PEGylated Dendritic Polyglycerol Conjugate Delivers Doxorubicin to the Parasitophorous Vacuole in Leishmania infantum Infections.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201700098
Abstract: Most drugs against visceral leishmaniasis must be administered parenterally. A controlled drug release at the target site can improve the efficacy and toxicity of antileishmanial drugs in clinical use. Amastigotes live and grow inside the… read more here.
Keywords: pegylated dendritic; conjugate; dendritic polyglycerol; parasitophorous vacuole ... See more keywords
Performance of a Flow-Through Enzyme Reactor Prepared from a Silica Monolith and an α-Poly(D-Lysine)-Enzyme Conjugate.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200465
Abstract: Horseradish peroxidase (HRP) is covalently bound in aqueous solution to polycationic α-poly(D-lysine) chains of approximately 1000 repeating units length, PDL, via a bis-aryl hydrazone bond (BAH). Under the experimental conditions used, about 15 HRP molecules… read more here.
Keywords: hrp; enzyme reactor; conjugate; monolith ... See more keywords
Full utilization of conjugate symmetry: combining virtual conjugate coil reconstruction with partial Fourier imaging for g‐factor reduction in accelerated MRI
Sign Up to like & getrecommendations! Published in 2019 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.27799
Abstract: In this study we propose a method to combine the parallel virtual conjugate coil (VCC) reconstruction with partial Fourier (PF) acquisition to improve reconstruction conditioning and reduce noise amplification in accelerated MRI where PF is… read more here.
Keywords: reconstruction; virtual conjugate; conjugate; reconstruction partial ... See more keywords
(Para-)Holomorphic and Conjugate Connections on (Para-)Hermitian and (Para-)Kähler Manifolds
Sign Up to like & getrecommendations! Published in 2019 at "Results in Mathematics"
DOI: 10.1007/s00025-019-1071-2
Abstract: We investigate how an affine connection $$\nabla $$ that generally admits torsion interacts with both g and L on an almost (para-)Hermitian manifold $$(\mathfrak {M},g,L)$$, where L denotes either an almost complex structure J with… read more here.
Keywords: torsion; nabla nabla; para hermitian; conjugate ... See more keywords
Preclinical development of the quadrivalent meningococcal (ACYW) tetanus toxoid conjugate vaccine, MenQuadfi®
Sign Up to like & getrecommendations! Published in 2022 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-022-10050-2
Abstract: Bacterial capsular polysaccharide vaccines are generally poorly immunogenic in infants and older adults. The immunogenicity of capsular polysaccharide vaccines can be improved by conjugating them to immunogenic carrier proteins. One of the most recently licensed… read more here.
Keywords: tetanus toxoid; development; conjugate; conjugate vaccine ... See more keywords
Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-019-9602-4
Abstract: The progression and metastasis of solid tumors strongly rely on the process of forming nascent blood vessels. However, using angiogenesis inhibitors alone does not meet the cancer treatment needs. Herein, we used the amphiphilic drug-drug… read more here.
Keywords: conjugate; drug; drug conjugate; antiangiogenesis ... See more keywords
Improved antioxidant, antimicrobial and anticancer activity of naringenin on conjugation with pectin
Sign Up to like & getrecommendations! Published in 2019 at "3 Biotech"
DOI: 10.1007/s13205-019-1835-0
Abstract: The purpose of the present study was to improve the aqueous solubility of naringenin by conjugating with water-soluble polysaccharide carrier, pectin. The pectin–naringenin conjugate was synthesized employing dicyclohexylcarbodiimide and dimethylaminopyridine. The conjugation was confirmed by… read more here.
Keywords: conjugate; pectin; naringenin conjugate; conjugation ... See more keywords
An improved Polak–Ribière–Polyak conjugate gradient method with an efficient restart direction
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Applied Mathematics"
DOI: 10.1007/s40314-021-01557-9
Abstract: For the large-scale optimization problems, we propose a new conjugate parameter by modifying the denominator of the Polak–Ribiere–Polyak formula, and give its non-negative form. Under the weak Wolfe line search, their corresponding algorithms perform superior… read more here.
Keywords: improved polak; restart direction; improved method; conjugate ... See more keywords
A hybrid conjugate finite-step length method for robust and efficient reliability analysis
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DOI: 10.1016/j.apm.2016.12.027
Abstract: Abstract The robustness and efficiency of the first-order reliability method (FORM) are the important issues in the structural reliability analysis. In this paper, a hybrid conjugate search direction with finite-step length is proposed to improve… read more here.
Keywords: conjugate; finite step; hybrid conjugate; reliability ... See more keywords