Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
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DOI: 10.1093/nar/gky037
Abstract: Abstract Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable delivery to target tissues. Partially modified siRNAs (up to 70% of the nucleotides) provide significant stabilization… read more here.
Keywords: fully chemically; mediated delivery; delivery; chemically modified ... See more keywords