1,3,2‐Diazaphospholenes Catalyze the Conjugate Reduction of Substituted Acrylic Acids
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DOI: 10.1002/cctc.202000662
Abstract: The potent nucleophilicity and remarkably low basicity of 1,3,2‐diazaphospholenes (DAPs) is exploited in a catalytic, metal‐free 1,4‐reduction of free α,β‐unsaturated carboxylic acids. Notably, the reduction occurs without a prior deprotonation of the carboxylic acid moiety… read more here.
Keywords: reduction; reduction substituted; catalyze conjugate; diazaphospholenes catalyze ... See more keywords
Enantio- and Regioselective CuH-Catalyzed Conjugate Reduction of Yne-Allenones.
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DOI: 10.1021/acs.orglett.1c00892
Abstract: A new asymmetric catalytic conjugate reduction of yne-allenones to synthesize enantioenriched cyclobuta[a]naphthalen-4(2H)-ones has been established that uses copper-bisphosphine complexes as catalysts and gives excellent regio- and enantioselectivities (≥99% ee) in most cases. This protocol tolerates… read more here.
Keywords: enantio regioselective; yne allenones; reduction yne; conjugate reduction ... See more keywords
Synthesis of Selenoesters via Aldol Condensation and/or Conjugate Reduction and Their Antiviral Activities
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DOI: 10.1021/acsomega.2c06784
Abstract: A variety of unsaturated selenoesters (including phenolic ones) were produced in good to high yields and with high E/Z ratios using TiCl4-promoted aldol condensation between Se-phenyl selenoacetate and their respective aldehydes without aqueous workup. A… read more here.
Keywords: antiviral activities; conjugate; conjugate reduction; reduction ... See more keywords