Improving efficacy of glycoconjugate vaccines: from chemical conjugates to next generation constructs.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2020.03.015
Abstract: Glycoconjugate vaccines are among the safest and most successful vaccines developed during the past 30 years. Since the first semisynthetic chemical conjugate vaccine licensed in the 1980's to protect human against Haemophilus influenzae type b… read more here.
Keywords: improving efficacy; efficacy glycoconjugate; chemical; glycoconjugate vaccines ... See more keywords
Impact of pneumococcal conjugate vaccines on otitis media: A review of measurement and interpretation challenges.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2017.07.009
Abstract: Acute otitis media (AOM) is among the most frequent childhood diseases and is caused by various bacterial and viral etiological agents. In this article, we provide an overview of published studies assessing the impact of… read more here.
Keywords: otitis media; vaccines otitis; pneumococcal conjugate; impact pneumococcal ... See more keywords
Pneumococcal carriage and serotype variation before and after introduction of pneumococcal conjugate vaccines in patients with acute otitis media in Switzerland.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.02.010
Abstract: BACKGROUND Acute otitis media (AOM) is an important cause for antibiotic prescription within the paediatric population and Streptococcus pneumoniae is a major pathogen associated with AOM episodes. This study aimed at analysing the influence of… read more here.
Keywords: carriage serotype; epidemiology; carriage; conjugate vaccines ... See more keywords
Invasive pneumococcal surveillance to assess the potential benefits of extended spectrum conjugate vaccines (PCV15/PCV20) in older adults
Sign Up to like & getrecommendations! Published in 2023 at "Epidemiology and Infection"
DOI: 10.1017/s0950268823000110
Abstract: Abstract The introduction of pneumococcal conjugate vaccines (PCV) into the childhood vaccination programme has reduced invasive pneumococcal disease (IPD). Although anticipated from data elsewhere, surveillance in Ireland has confirmed reductions in IPD amongst those ⩾65… read more here.
Keywords: invasive pneumococcal; conjugate vaccines; pneumococcal surveillance; surveillance assess ... See more keywords
Validation of an FFF-MALS Method to Characterize the Production and Functionalization of Outer-Membrane Vesicles for Conjugate Vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c01590
Abstract: With the ongoing development of conjugate vaccines battling infectious diseases, there is a need for novel carriers. Although tetanus toxoid and CRM197 belong to the traditional carrier proteins, outer-membrane vesicles (OMVs) are an excellent alternative:… read more here.
Keywords: mals method; validation; outer membrane; conjugate vaccines ... See more keywords
Profiling Germinal Center-like B Cell Responses to Conjugate Vaccines Using Synthetic Immune Organoids
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01473
Abstract: Glycoengineered bacteria have emerged as a cost-effective platform for rapid and controllable biosynthesis of designer conjugate vaccines. However, little is known about the engagement of such conjugates with naïve B cells to induce the formation… read more here.
Keywords: cell; like cell; center like; conjugate vaccines ... See more keywords
Structure Guided Design of Bacteriophage Qβ Mutants as Next Generation Carriers for Conjugate Vaccines.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00906
Abstract: Vaccines are critical tools to treat and prevent diseases. For an effective conjugate vaccine, the carrier is crucial, but few carriers are available for clinical applications. In addition, a drawback of current protein carriers is… read more here.
Keywords: structure; conjugate vaccines; next generation; vaccine ... See more keywords
Development in the Concept of Bacterial Polysaccharide Repeating Unit-Based Antibacterial Conjugate Vaccines.
Sign Up to like & getrecommendations! Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00559
Abstract: The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx. The complex glycans in the glycocalyx are involved in various biological events, such as bacterial pathogenesis, protection of… read more here.
Keywords: polysaccharide repeating; bacterial polysaccharide; unit based; development ... See more keywords
Comprehensive value assessments for new pediatric pneumococcal conjugate vaccines
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Economics"
DOI: 10.1080/13696998.2021.1970974
Abstract: Abstract Although the incidence of invasive pneumococcal disease (IPD) and acute otitis media (AOM) in young children has decreased since the introduction of pneumococcal conjugate vaccines (PCVs), the subsequent emergence of non-vaccine Streptococcus pneumoniae serotypes… read more here.
Keywords: pneumococcal conjugate; conjugate vaccines; burden; vaccine ... See more keywords
Safety and immunogenicity of pneumococcal conjugate vaccines in preterm infants
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2019.1597849
Abstract: ABSTRACT Introduction: The introduction of pneumococcal conjugate vaccines (PCVs) in the routine immunization program has resulted in a significant decline in invasive pneumococcal diseases (IPD) around the world. Preterm infants are a special group at… read more here.
Keywords: immunogenicity; safety; preterm infants; conjugate vaccines ... See more keywords
The broader impacts of otitis media and sequelae for informing economic evaluations of pneumococcal conjugate vaccines
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2022.2040989
Abstract: ABSTRACT Introduction Otitis media (OM) is a common childhood infection. Pneumococcal conjugate vaccines (PCVs) prevent OM episodes, thereby reducing short- and long-term clinical, economic, humanistic, and societal consequences. Most economic evaluations of PCVs focus on… read more here.
Keywords: pneumococcal conjugate; otitis media; conjugate vaccines; evaluations pcvs ... See more keywords