Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR
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DOI: 10.1158/1535-7163.mct-20-0351
Abstract: Resistance to antibody–drug conjugates (ADCs) has been observed in both preclinical models and clinical studies. However, mechanisms of resistance to pyrrolobenzodiazepine (PBD)-conjugated ADCs have not been well characterized and thus, this study was designed to… read more here.
Keywords: pbd; resistance pyrrolobenzodiazepine; pbd conjugated; conjugated adcs ... See more keywords