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   Articles with "conjugated antisense" as a keyword



Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2113180119

Abstract: Significance We report a molecular brush-based oligonucleotide therapeutics platform which uniquely provides conjugated antisense oligonucleotides with binding selectivity, improved pharmacological properties, and an unusual biodistribution profile. These improvements lead to superior in vivo performance compared… read more here.

Keywords: conjugated antisense; targeting oncogenic; antisense oligonucleotides; oncogenic kras ... See more keywords

N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels

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recommendations! Published in 2019 at "European Heart Journal"

DOI: 10.1093/eurheartj/ehz209

Abstract: Abstract Aims Elevated apolipoprotein C-III (apoC-III) levels are associated with hypertriglyceridaemia and coronary heart disease. AKCEA-APOCIII-LRx is an N-acetyl galactosamine-conjugated antisense oligonucleotide targeted to the liver that selectively inhibits apoC-III protein synthesis. Methods and results… read more here.

Keywords: akcea apociii; galactosamine conjugated; acetyl galactosamine; apociii lrx ... See more keywords

Comparison of Pharmacokinetics of the GalNAc-Conjugated Antisense Oligonucleotide GSK3389404 in Participants with Chronic Hepatitis B Infection across the Asia-Pacific Region

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recommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00900-22

Abstract: GSK3389404, an N-acetyl galactosamine-conjugated antisense oligonucleotide (ASO), was in clinical development for chronic hepatitis B (CHB) treatment. Few studies have examined ASOs in Asian participants. ABSTRACT GSK3389404, an N-acetyl galactosamine-conjugated antisense oligonucleotide (ASO), was in… read more here.

Keywords: conjugated antisense; antisense oligonucleotide; asia pacific; chronic hepatitis ... See more keywords