Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody-Drug Conjugate with Cleavable Linker.
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DOI: 10.1021/acs.bioconjchem.6b00695
Abstract: As antibody-drug conjugate (ADC) design is evolving with novel payload, linker, and conjugation chemistry, the need for sensitive and precise quantitative measurement of conjugated payload to support pharmacokinetics (PK) is in high demand. Compared to… read more here.
Keywords: chemistry; drug conjugate; conjugated payload; linker ... See more keywords