Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs).
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DOI: 10.1093/nar/gkad415
Abstract: Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated in rodents, effectiveness and pharmacokinetic/pharmacodynamic (PKPD) properties remained unknown in higher species. We developed antibody-oligonucleotide conjugates (AOCs) towards mice or monkeys utilizing anti-TfR1… read more here.
Keywords: muscle; conjugates aocs; antibody oligonucleotide; oligonucleotide conjugates ... See more keywords