Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery
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DOI: 10.1002/open.201900110
Abstract: Abstract RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable linkers. The conjugates were able to effectively inhibit binding… read more here.
Keywords: conjugates cryptophycin; drug delivery; drug; isodgr ... See more keywords