PNA Conjugates of Quinone Methide Precursors Alkylate RNA after Activation with Light.
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DOI: 10.1021/acs.bioconjchem.9b00796
Abstract: Quinone methide precursors 2 and 3 were protected with a photoreactive 2-nitrobenzyl group and conjugated to peptide nucleic acids (PNA) using a Huisgen click reaction. After brief irradiation at 365 nm, crosslinking with com-plementary RNA… read more here.
Keywords: quinone methide; alkylate rna; methide precursors; precursors alkylate ... See more keywords