Abstract P4-04-27: Next generation antibody drug conjugates targeting HER2 and TROP2: Multi-Payload Conjugates™ targeting orthogonal mechanisms of cell killing
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DOI: 10.1158/1557-3265.sabcs24-p4-04-27
Abstract: Introduction: Antibody-Drug Conjugates (ADCs) have had tremendous impact on patient outcomes in breast cancer and are now second-line therapy for stage IV HER2 high expressing metastatic breast cancer as well as HER2 low expressing tumors.… read more here.
Keywords: multi payload; payload conjugates; her2 trop2; conjugates targeting ... See more keywords
Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer
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DOI: 10.3389/fchem.2019.00369
Abstract: Due to its central role in the cellular biology of prostate cancer (PC), androgen receptor (AR) still remains an important therapeutic target for fighting this tumor. Several drugs targeting AR have been reported so far,… read more here.
Keywords: receptor; androgen receptor; prostate cancer; conjugates targeting ... See more keywords
Drug Conjugates for Targeting Eph Receptors in Glioblastoma
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DOI: 10.3390/ph13040077
Abstract: Glioblastoma (GBM) is a complex and heterogeneous tumor that warrants a comprehensive therapeutic approach for treatment. Tumor-associated antigens offer an opportunity to selectively target various components of the GBM microenvironment while sparing the normal cells… read more here.
Keywords: drug conjugates; eph receptors; targeting eph; conjugates targeting ... See more keywords