Chemical Synthesis of Atomically Tailored SUMO E2 Conjugating Enzymes for the Formation of Covalently Linked SUMO-E2-E3 Ligase Ternary Complexes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b06820
Abstract: E2 conjugating enzymes are the key catalytic actors in the transfer of ubiquitin, SUMO, and other ubiquitin-like modifiers to their substrate proteins. Their high rates of transfer and promiscuous binding complicate studies of their interactions… read more here.
Keywords: covalently linked; sumo conjugating; ligation; conjugating enzymes ... See more keywords
E2 ubiquitin-conjugating enzymes (UBCs): drivers of ubiquitin signalling in plants.
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DOI: 10.1042/ebc20210093
Abstract: Most research in the field of ubiquitination has focused on E3 ubiquitin ligases because they are the specificity determinants of the ubiquitination process. Nevertheless, E2s are responsible for the catalysis during ubiquitin transfer, and are… read more here.
Keywords: ubiquitin signalling; enzymes ubcs; ubcs drivers; drivers ubiquitin ... See more keywords
The UBE2D ubiquitin conjugating enzymes: Potential regulatory hubs in development, disease and evolution
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1058751
Abstract: Ubiquitination of cellular proteins plays critical roles in key signalling pathways and in the regulation of protein turnover in eukaryotic cells. E2 ubiquitin conjugating enzymes function as essential intermediates in ubiquitination reactions by acting as… read more here.
Keywords: development; ube2d ubiquitin; conjugating enzymes; regulation ... See more keywords
Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review)
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DOI: 10.3892/or.2023.8500
Abstract: Digestive system cancers are the leading cause of cancer-related death worldwide due to their high morbidity and mortality rates. The current treatment methods include surgical treatment, chemotherapy, radiotherapy and endoscopic treatment, and the precisely targeted… read more here.
Keywords: system; digestive system; system cancers; conjugating enzymes ... See more keywords