Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport Flow in a Cellular Negative Feedback Loop
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DOI: 10.1002/advs.202201414
Abstract: Bile acid‐modified nanoparticles provide a convenient strategy to improve oral bioavailability of poorly permeable drugs by exploiting specific interactions with bile acid transporters. However, the underlying mechanisms are unknown, especially considering the different absorption sites… read more here.
Keywords: acid; transport; negative feedback; conjugation ... See more keywords
Enlarging the Stokes Shift by Weakening the π‐Conjugation of Cyanines for High Signal‐to‐Noise Ratiometric Imaging
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DOI: 10.1002/advs.202205080
Abstract: The signal‐to‐noise ratio (SNR) is one of the key features of a fluorescent probe and one that often defines its potential utility for in vivo labeling and analyte detection applications. Here, it is reported that… read more here.
Keywords: shift weakening; enlarging stokes; stokes shift; conjugation ... See more keywords
Conjugation of a Toll‐Like Receptor Agonist to Glycans of an HIV Native‐Like Envelope Trimer Preserves Neutralization Epitopes
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200236
Abstract: Small molecule adjuvants are attractive for enhancing broad protection and durability of immune responses elicited by subunit vaccines. Covalent attachment of an adjuvant to an immunogen is particularly attractive because it simultaneously delivers both entities… read more here.
Keywords: envelope trimer; native like; toll like; like receptor ... See more keywords
Chemical Conjugation to Less Targeted Proteinogenic Amino Acids
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DOI: 10.1002/cbic.202200245
Abstract: Protein bioconjugates are in high demand for applications in biomedicine, diagnostics, chemical biology and bionanotechnology. Proteins are large and sensitive molecules containing multiple different functional groups and in particular nucleophilic groups. In bioconjugation reactions it… read more here.
Keywords: amino acids; less targeted; conjugation less; conjugation ... See more keywords
Inhibiting conjugation as a tool in the fight against antibiotic resistance
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21457
Abstract: Antibiotic resistance, especially in gram‐negative bacteria, is spreading globally and rapidly. Development of new antibiotics lags behind; therefore, novel approaches to the problem of antibiotic resistance are sorely needed and this commentary highlights one relatively… read more here.
Keywords: conjugation tool; tool fight; resistance; inhibiting conjugation ... See more keywords
Utilizing functionalized bromomaleimides for fluorogenic conjugation and PEGylation of enzymes
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DOI: 10.1002/pi.5740
Abstract: Two efficient enzyme conjugation techniques have been explored by exploiting the reactions of bromomaleimides. The conjugations utilize monobromoand dibromomaleimides, which have been reacted with reduced disulfide bonds or terminal amines in α-chymotrypsin and human lysozyme.… read more here.
Keywords: conjugation; functionalized bromomaleimides; utilizing functionalized; pegylation ... See more keywords
Regulating π-Conjugation in sp2 -Carbon-Linked Covalent Organic Frameworks for Efficient Metal-Free CO2 Photoreduction with H2 O.
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DOI: 10.1002/smll.202208118
Abstract: The development of sp2 -carbon-linked covalent organic frameworks (sp2 c-COFs) as artificial photocatalysts for solar-driven conversion of CO2 into chemical feedstock has captured growing attention, but catalytic performance has been significantly limited by their intrinsic… read more here.
Keywords: conjugation; co2; co2 photoreduction; sp2 carbon ... See more keywords
Energy Storage Application of Conducting Polymers Featuring Dual Acceptors: Exploring Conjugation and Flexible Chain Length Effects.
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DOI: 10.1002/smll.202300689
Abstract: Solution-processable conducting polymers (CPs) are a compelling alternative to inorganic counterparts because of their potential for tuning chemical properties and creating flexible organic electronics. CPs, which typically comprise either only an electron donor (D) or… read more here.
Keywords: energy; conducting polymers; conjugation; length ... See more keywords
SnoopLigase-Mediated Peptide-Peptide Conjugation and Purification.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0928-6_2
Abstract: Covalently linking together different proteins can enhance functionality for a range of applications. We have developed the SnoopLigase peptide-peptide conjugation method to easily and specifically link proteins fused to the peptides SnoopTagJr or DogTag via… read more here.
Keywords: snoopligase mediated; peptide peptide; peptide conjugation; conjugation ... See more keywords
Introduction of Genetic Material in Ralstonia solanacearum Through Natural Transformation and Conjugation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7604-1_16
Abstract: Ralstonia solanacearum is a soil-borne plant pathogen, responsible of the bacterial wilt disease. Its unusual wide host range (more than 250 plant species), aggressiveness, and broad geographic distribution have made of this bacterium the main… read more here.
Keywords: conjugation; solanacearum; natural transformation; ralstonia solanacearum ... See more keywords
Site-Specific Antibody-Drug Conjugation Using Microbial Transglutaminase.
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DOI: 10.1007/978-1-4939-9546-2_8
Abstract: Antibody-drug conjugates (ADCs) are a relatively young class of cancer therapeutics that combine the superior selectivity of monoclonal antibodies (mAbs) with the high potency of cytotoxic agents. In the first generation of ADCs, the toxic… read more here.
Keywords: site specific; antibody drug; drug; conjugation ... See more keywords