Enhanced Liver Targeting of Camptothecin via Conjugation with Deoxycholic Acid
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DOI: 10.3390/molecules24061179
Abstract: Camptothecin (CPT) shows potent anticancer activity through inhibition of topoisomerase I. However, its water insolubility and severe toxicity limit its clinical application. Coupling with bile acid moieties is a promising method for liver-targeted drug delivery,… read more here.
Keywords: liver targeting; cpt; camptothecin; deoxycholic acid ... See more keywords