IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma
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DOI: 10.1038/s41388-021-02111-x
Abstract: As the p53 tumor suppressor is rarely mutated in conjunctival melanoma (CM), we investigated its activation as a potential therapeutic strategy. Preventing p53/Mdm2 interaction by Nutlin-3, the prototypical Mdm2 antagonist, or via direct siRNA Mdm2… read more here.
Keywords: p53 reactivation; igf; conjunctival melanoma; p53 ... See more keywords
Management of conjunctival melanoma with local excision and adjuvant brachytherapy
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DOI: 10.1038/s41433-020-0879-z
Abstract: Background/objectives To evaluate the management of conjunctival melanoma with local excision and adjuvant brachytherapy. Subjects/methods Data of all patients who received local excision and adjuvant brachytherapy for conjunctival melanoma between 1999 and 2016 in a… read more here.
Keywords: adjuvant brachytherapy; local excision; excision adjuvant; conjunctival melanoma ... See more keywords
Orbital exenteration for conjunctival melanoma: comparison of long-term outcome between individualised and conventional techniques
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DOI: 10.1038/s41433-021-01454-9
Abstract: Growing evidence supports an individualised approach rather than radical surgery for conjunctival melanoma (CM). This study aimed to compare the long-term outcome between individualised and conventional exenteration techniques. Our study retrospectively recruited advanced CM (clinical… read more here.
Keywords: exenteration; outcome individualised; long term; term outcome ... See more keywords
Transcriptional characterization of conjunctival melanoma identifies the cellular tumor microenvironment and prognostic gene signatures
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72864-0
Abstract: This study characterizes the transcriptome and the cellular tumor microenvironment (TME) of conjunctival melanoma (CM) and identifies prognostically relevant biomarkers. 12 formalin-fixed and paraffin-embedded CM were analyzed by MACE RNA sequencing, including six cases each… read more here.
Keywords: melanoma identifies; cellular tumor; conjunctival; conjunctival melanoma ... See more keywords
Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc01646j
Abstract: In vivo data are rare but essential for establishing the clinical potential of ruthenium-based photoactivated chemotherapy (PACT) compounds, a new family of phototherapeutic drugs that are activated via ligand photosubstitution. Here a novel trisheteroleptic ruthenium… read more here.
Keywords: melanoma; pact; conjunctival melanoma; ruthenium ... See more keywords
Conjunctival Melanoma in Asian Indians: A Study of 42 Patients
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in Ophthalmology"
DOI: 10.1080/08820538.2019.1620793
Abstract: ABSTRACT Purpose: To describe the clinical features, treatment, and outcomes of conjunctival melanoma in Asian Indians. Methods: Retrospective study of 42 patients. Results: The mean age at presentation of conjunctival melanoma was 43 years (median,… read more here.
Keywords: study patients; asian indians; melanoma asian; conjunctival melanoma ... See more keywords
Ocular Argyrosis Mimicking Conjunctival Melanoma
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DOI: 10.1097/ico.0000000000001191
Abstract: Purpose: To present a novel case of ocular argyrosis mimicking conjunctival melanoma. Methods: A 48-year-old man who is a jewelry manufacturer presented with raised pigmented lesions in the inferior fornices of both eyes. Brown-black colored,… read more here.
Keywords: mimicking conjunctival; argyrosis mimicking; conjunctival melanoma; argyrosis ... See more keywords
Two cases of BRAF‐mutated, bulbar conjunctival melanoma, and review of the published literature
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.14060
Abstract: We describe two patients with BRAF‐mutated melanoma of the epithelioid cell type arising from primary acquired melanosis with severe atypia of the right bulbar conjunctiva. Patient 1 was a 71‐year‐old Japanese man. After adjuvant cryotherapy… read more here.
Keywords: bulbar; braf mutated; two cases; conjunctival melanoma ... See more keywords
Treatment of conjunctival melanoma in a Dutch referral centre
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DOI: 10.1136/bjophthalmol-2017-311082
Abstract: Aims To evaluate the treatment of conjunctival melanoma at a large Dutch referral centre and to make recommendations for clinical management. Methods A retrospective review was performed of clinical and histological data of 70 patients… read more here.
Keywords: melanoma; referral centre; treatment; conjunctival melanoma ... See more keywords
Invasive conjunctival melanoma mimicking ocular surface squamous neoplasia: a case series
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DOI: 10.1136/bjophthalmol-2019-315393
Abstract: Background Conjunctival melanoma is the second most common conjunctival malignant tumour after squamous cell carcinoma, usually arising from primary acquired melanosis and less commonly from a conjunctival naevus or de novo. We report four cases… read more here.
Keywords: surface squamous; ocular surface; conjunctival; conjunctival melanoma ... See more keywords
Eye-Sparing Treatment for Diffuse Invasive Conjunctival Melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Ocular Oncology and Pathology"
DOI: 10.1159/000485978
Abstract: The management of patients with diffuse invasive conjunctival melanoma focuses on local tumor control and screening for metastasis. Despite the lack of consensus on the benefit of sentinel lymph node biopsy for these neoplasms, the… read more here.
Keywords: tumor; conjunctival melanoma; diffuse invasive; invasive conjunctival ... See more keywords