Backbone Circularization Coupled with Optimization of Connecting Segment in Effectively Improving the Stability of Granulocyte-Colony Stimulating Factor.
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DOI: 10.1021/acschembio.7b00776
Abstract: Backbone circularization of protein is a powerful method to improve its structural stability. In this paper, we presumed that a tight connection leads to much higher stability. Therefore, we designed circularized variants of a granulocyte-colony… read more here.
Keywords: backbone circularization; colony stimulating; granulocyte colony; connecting segment ... See more keywords