Gene expression profiling coupled with Connectivity Map database mining reveals potential therapeutic drugs for Hirschsprung disease.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pediatric surgery"
DOI: 10.1016/j.jpedsurg.2018.02.060
Abstract: BACKGROUND Hirschsprung disease (HD) is a congenital intestinal anomaly resulting from a failure to form enteric ganglia in the lower bowel. Surgery is the main therapeutic strategy, although neural stem cell transplantation has recently shown… read more here.
Keywords: expression; connectivity map; hirschsprung disease; disease ... See more keywords
Improving deconvolution methods in biology through open innovation competitions: an application to the connectivity map
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab192
Abstract: Abstract Motivation Do machine learning methods improve standard deconvolution techniques for gene expression data? This article uses a unique new dataset combined with an open innovation competition to evaluate a wide range of approaches developed… read more here.
Keywords: deconvolution methods; connectivity map; biology; deconvolution ... See more keywords
Induction of neuronal differentiation in glioma cells by histone deacetylase inhibitors based on Connectivity Map discovery
Sign Up to like & getrecommendations! Published in 2024 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001667
Abstract: Neuron conversion leads to proliferation inhibition of glioma cells and may be an effective strategy to combat glioma and prevent recurrence. In this study, drug repositioning based on Connectivity Map (CMap) was conducted to discover… read more here.
Keywords: differentiation glioma; based connectivity; glioma cells; connectivity map ... See more keywords
Resveratrol inhibits development of colorectal adenoma via suppression of LEF1; comprehensive analysis with connectivity map
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15576
Abstract: Although many chemopreventive studies on colorectal tumors have been reported, no effective and safe preventive agent is currently available. We searched for candidate preventive compounds against colorectal tumor comprehensively from United States Food and Drug… read more here.
Keywords: resveratrol; colorectal adenoma; suppression lef1; analysis ... See more keywords
Rapid Discovery of Potential Drugs for Osteonecrosis of Femoral Head Based on Gene Expression Omnibus Database and Connectivity Map
Sign Up to like & getrecommendations! Published in 2019 at "Orthopaedic Surgery"
DOI: 10.1111/os.12533
Abstract: To use Gene Expression Omnibus (GEO) database coupled with Connectivity Map (CMap) databases to screen potential therapeutic drugs for osteonecrosis of femoral head (ONFH) rapidly. read more here.
Keywords: osteonecrosis femoral; femoral head; connectivity map; gene expression ... See more keywords
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Biology"
DOI: 10.1371/journal.pbio.2003213
Abstract: The application of RNA interference (RNAi) to mammalian cells has provided the means to perform phenotypic screens to determine the functions of genes. Although RNAi has revolutionized loss-of-function genetic experiments, it has been difficult to… read more here.
Keywords: target effects; connectivity map; gene expression; rnai ... See more keywords
Connectivity Map Analysis Indicates PI3K/Akt/mTOR Inhibitors as Potential Anti-Hypoxia Drugs in Neuroblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13112809
Abstract: Simple Summary A large percentage of patients with neuroblastoma relapse and die, despite treatment, thus demanding new personalized strategies and therapeutic targets. Hypoxia, a condition of reduced oxygenation in several solid tumors, has profound effects… read more here.
Keywords: mtor inhibitors; analysis; connectivity map; pi3k akt ... See more keywords
Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21207695
Abstract: Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD). Serum uric acid (SUA) levels in CKD stage 3–4 patients closely correlate with hyperuricemic nephropathy (HN) morbidity. New uric acid (UA)-lowering strategies are required… read more here.
Keywords: multiple purpose; fibrosis; connectivity map; renal fibrosis ... See more keywords
Bioinformatics and Connectivity Map Analysis Suggest Viral Infection as a Critical Causative Factor of Hashimoto’s Thyroiditis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021157
Abstract: Hashimoto’s thyroiditis (HT) is a common autoimmune disease, and its prevalence is rapidly increasing. Both genetic and environmental risk factors contribute to the development of HT. Recently, viral infection has been suggested to act as… read more here.
Keywords: viral infection; hashimoto thyroiditis; infection; analysis ... See more keywords
Identification of phenothiazine as an ETV1‑targeting agent in gastrointestinal stromal tumors using the Connectivity Map.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of oncology"
DOI: 10.3892/ijo.2019.4829
Abstract: Gastrointestinal stromal tumors (GISTs) are gastrointestinal tract sarcomas that commonly contain a mutation in the tyrosine kinases, KIT and platelet‑derived growth factor receptor A (PDGFRA). Imatinib, sunitinib and regorafenib are all effective tyrosine kinase inhibitors; however, acquired… read more here.
Keywords: phenothiazine; connectivity map; etv1; gastrointestinal stromal ... See more keywords