Navigating Transcriptomic Connectivity Mapping Workflows to Link Chemicals with Bioactivities.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00245
Abstract: Screening new compounds for potential bioactivities against cellular targets is vital for drug discovery and chemical safety. Transcriptomics offers an efficient approach for assessing global gene expression changes, but interpreting chemical mechanisms from these data… read more here.
Keywords: toxicology; gene; connectivity mapping; chemical ... See more keywords
An integrated meta-analysis approach to identifying medications with potential to alter breast cancer risk through connectivity mapping
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1989-x
Abstract: BackgroundGene expression connectivity mapping has gained much popularity in recent years with a number of successful applications in biomedical research testifying its utility and promise. A major application of connectivity mapping is the identification of… read more here.
Keywords: cancer; gene; connectivity mapping; breast cancer ... See more keywords
Analysis of gene expression and use of connectivity mapping to identify drugs for treatment of human glomerulopathies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1122328
Abstract: Background Human glomerulonephritis (GN)—membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS) and IgA nephropathy (IgAN), as well as diabetic nephropathy (DN) are leading causes of chronic kidney disease. In these glomerulopathies, distinct stimuli disrupt metabolic pathways… read more here.
Keywords: identify drugs; connectivity mapping; expression; upr autophagy ... See more keywords
Functional Connectivity Mapping in the Animal Model: Principles and Applications of Resting-State fMRI
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DOI: 10.3389/fneur.2017.00200
Abstract: “Resting-state” fMRI has substantially contributed to the understanding of human and non-human functional brain organization by the analysis of correlated patterns in spontaneous activity within dedicated brain systems. Spontaneous neural activity is indirectly measured from… read more here.
Keywords: functional connectivity; connectivity mapping; connectivity; resting state ... See more keywords