A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.100800
Abstract: Summary More than six decades have passed since the discovery of monoaminergic antidepressants. Yet, it remains a mystery why these drugs take weeks to months to achieve therapeutic effects, although their monoaminergic actions are present… read more here.
Keywords: predates predicts; fingerprint; predicts response; connectome fingerprint ... See more keywords
A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00864-9
Abstract: Over the past decade, various N -methyl- d -aspartate modulators have failed in clinical trials, underscoring the challenges of developing novel rapid-acting antidepressants based solely on the receptor or regional targets of ketamine. Thus, identifying… read more here.
Keywords: robust reproducible; ketamine; connectivity; connectome fingerprint ... See more keywords