Connexin-Based Channels in the Liver.
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DOI: 10.1002/cphy.c220007
Abstract: Connexin proteins oligomerize in hexameric structures called connexin hemichannels, which then dock to form gap junctions. Gap junctions direct cell-cell communication by allowing the exchange of small molecules and ions between neighboring cells. In this… read more here.
Keywords: connexin based; based channels; channels liver; gap junctions ... See more keywords
Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice
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DOI: 10.1038/s41598-017-08583-w
Abstract: While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress. The latter are essential features of non-alcoholic steatohepatitis. In this study, it… read more here.
Keywords: non alcoholic; alcoholic steatohepatitis; connexin hemichannels; steatohepatitis mice ... See more keywords
Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213162119
Abstract: Significance Although symptomatic medications are available, many temporal lobe epilepsy (TLE) patients remain unresponsive to treatment and new drug targets are needed. Connexin-based gap junctions and hemichannels in brain glial cells are implicated in TLE,… read more here.
Keywords: temporal lobe; connexin hemichannels; connexin; lobe epilepsy ... See more keywords
The Role of Connexin Hemichannels in Inflammatory Diseases
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DOI: 10.3390/biology11020237
Abstract: Simple Summary Connexin hemichannels are formed by connexin protein family members, and connect cytosol and extracellular milium. The function of connexin hemichannels cannot be readily distinguished from the gap junctions formed also by connexins, or… read more here.
Keywords: inflammatory diseases; role connexin; cxhc; connexin hemichannels ... See more keywords
The Potential for Connexin Hemichannels to Drive Breast Cancer Progression through Regulation of the Inflammatory Response
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DOI: 10.3390/ijms19041043
Abstract: Over the past few decades, connexin hemichannels have become recognized as major players in modulating the inflammatory response. Chronic inflammation is documented to promote tumorigenesis and is a critical component of tumor progression. Furthermore, inflammation… read more here.
Keywords: breast; breast cancer; connexin hemichannels; connexin ... See more keywords
CO2-Sensitive Connexin Hemichannels in Neurons and Glia: Three Different Modes of Signalling?
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22147254
Abstract: Connexins can assemble into either gap junctions (between two cells) or hemichannels (from one cell to the extracellular space) and mediate cell-to-cell signalling. A subset of connexins (Cx26, Cx30, Cx32) are directly sensitive to CO2… read more here.
Keywords: modes signalling; neurons glia; sensitive connexin; connexin hemichannels ... See more keywords